Clinical Medicine
Comparison of effects of metaraminol and norepinephrine on elderly patients with septic shock
Ma Linqin, Zhang Jiaqi, Liu Yi, Wu Caijun
Published 2020-04-10
Cite as Chin J Emerg Med, 2020, 29(4): 547-550. DOI: 10.3760/cma.j.issn.1671-0282.2020022.008-2
Abstract
ObjectiveTo compare the effect of metaraminol and norepinephrine (NA) on elderly patients with septic shock.
MethodsIn this multicenter prospective cohort study elderly patients with septic shock were divided into the metaraminol group (n=100) and NA group (n=100). The 28-day survival and average hospital stay, the hemodynamics and renal function of the patients were observed.
ResultsThe average hospital stay in the metaraminol group was lower than that in the NA group (P < 0.05). Blood pressure, heart rate, arterial lactate, B-type natriuretic peptide, left ventricular ejection fraction and 28-day survival had no significant differences between the two groups (all P > 0.05). The average urine output at day 3 and 7 after the administration of vasopressor in the metaraminol group were higher than those in the NA group (all P< 0.05), blood urea nitrogen at day 3, 7 and 14 after the administration of vasopressor in the metaraminol group were lower than those in the NA group (all P < 0.05), and the creatinine at day 3, 7 and 14 after the administration of vasopressor and the rate of renal replacement therapy in the metaraminol group were lower than those in the NA group (all P < 0.05).
ConclusionsMetaraminol has similar effect to norepinephrine in improving 28-day survival and hemodynamics of elderly patients with septic shock, but is superior to norepinephrine in reducing the average hospital stay and protecting renal function.
Key words:
Elderly patients; Sepsis; Septic shock; Metaraminol; Norepinephrine; Vesoactive drugs; Renal function
Contributor Information
Ma Linqin
Institute of Sepsis, University of Chinese Medicine, Beijing, 100700
Zhang Jiaqi
Department of Emergency Medicine, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, 100700
Liu Yi
Department of Emergency Medicine, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, 100700
Wu Caijun
Department of Emergency Medicine, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, 100700
Institute of Sepsis, University of Chinese Medicine, Beijing, 100700
