One hundred and seventy one gastric biopsy specimens from the patients undergoing gastroscopic examination from March to November 2010 were reviewed. HE, sliver and immunohistochemistry stains were performed in the specimens; the correlation of histopatholigy and the density and distribution of Helicobacter pylori in gastric mucosa was analyzed. The results displayed that spiral H. pylori mainly appeared on the surface mucus and in the gland lumen of gastric small concave, some were attached to the epithelial cells; coccoid H. pylori appeared within the apical cytoplasmic part of the epithelial cells and in the mucous membrane stroma. The depth of H. pylori infection was correlated with mucosal erosion, inflammation activities and amount of interstitial lymphocytes. The results suggest that spiral H. pylori infection may facilitate the invasive depth of coccoid H. pylori in gastric mucous membrane and the density of H. pylori infection is correlated with the extent and severity of inflammation.

Helicobacter pylori; Gastric mucosa