Review
Recent advance in neuroprotection effect of salvia miltiorrhiza on central nervous system and related toxicology
Zhou Longyun, Cui Xuejun, Chen Xuqing, Yao Min, Liu Shufen, Tian Zirui, Wang Yongjun
Published 2019-02-15
Cite as Chin J Neuromed, 2019, 18(2): 199-206. DOI: 10.3760/cma.j.issn.1671-8925.2019.02.017
Abstract
Recently, salvia miltiorrhiza has made a great progress in research of central nervous system (CNS) injury and neurodegeneration. Salvia miltiorrhiza and its active ingredients can exert multiple effects involving reduction of cell loss, attenuation of oxidative stress, improvement of micro-circulation and promotion of neuroregeneration, and show a protective effect on CNS diseases. Regulation of oxidative stress and removing accumulated metabolite may be the important mechanisms by which salvia miltiorrhiza exerts neuroprotective effects. This study will systematically discuss the pharmacological effects and possible mechanisms of salvia miltiorrhiza based on the core pathological changes in CSN diseases, and evaluate its drug safety through combing the related toxicology researches to provide a reference for clinical transformation of Chinese medicine in threatment of CNS diseases.
Key words:
Salvia miltiorrhiza; Active ingredient; Neuroprotection; Toxicology
Contributor Information
Zhou Longyun
Rehabilitation Medicine School, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Cui Xuejun
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Chen Xuqing
Department of Otorhinolaryngology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210000, China
Yao Min
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Liu Shufen
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Tian Zirui
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Wang Yongjun
Rehabilitation Medicine School, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Faculty of Basic Medicine, Research Institute of Spine Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
