To analyze the modifiable risk factors for early-onset Alzheimer's disease (EOAD), and provide evidence for primary prevention of EOAD.

Forty patients with EOAD, admitted to our hospital from January 2015 to April 2020, were selected as EOAD group, and 120 healthy controls accepted physical examination and matched with EOAD patients in age, gender and education level were selected. Demographic characteristics and clinical data of patients from the EOAD group and subjects from the control group were compared retrospectively, and multivariate Logistic regression was used to analyze the independent risk factors for onset of EOAD.

As compared with the control group, the EOAD group had significantly higher proportion of patients with hypertension, non-traumatic tooth loosening or loss, history of traumatic brain injury, hearing impairment, chronic stress and/or anxiety, and sleep disorder (P<0.05). The results of multivariate Logistic regression analysis showed that hypertension (OR=4.559, 95%CI=1.523-13.643, P=0.007), non-traumatic loss or loosing of tooth (OR=5.345, 95%CI=1.989-14.346, P=0.001), hearing impairment (OR=9.336, 95%CI=2.033-27.850, P=0.000), chronic stress and/or anxiety (OR=7.375, 95%CI=2.612-20.822, P=0.000), and sleep disorder (OR=4.875, 95%CI=1.520-15.625, P=0.002) were independent risk factors for onset of EOAD.

Hypertension, non-traumatic loss or loosing of tooth, hearing impairment, chronic stress and/or anxiety, and sleep disorders are risk factors for onset of EOAD; the screening and intervention of these risk factors can be used as a primary prevention strategy for EOAD.

Early onset Alzheimer's disease; Modifiable risk factor; Case control study; Primary prevention