To discuss the feasibility and clinical efficacy of zhigancao decoction for the treatment of senile coronary heart disease.

174 cases aged more than 60 of Liaocheng municipal hospital of Traditional Chinese Medicine were divided into a control group and an observation group by the random number table method from April 2012 to April. 2014. 87 cases in the control group were treated with conventional western medicine, while 87 cases in the observation group were taken zhigancao decoction. The clinical efficacy, changes of hemorheology in both groups were observed and compared.

The total effective rate of angina was 67.8% in the control group and 89.7% in the observation group, with obvious difference (χ²=11.122, P=0.001). The total effective rate of electrocardiogram was 62.1% in the control group and 80.5% in the observation group, with obvious difference (χ²=14.771, P<0.01). The change of hemorheology blood viscosity (1.48 ± 0.31 mPa•s vs. 1.61 ± 0.29 mPa•s, t=2.856), whole blood viscosity ow cut (l 6.01 ± 0.85 mPa•s vs. 6.42 ± 1.34 mPa•s, t=2.410) and high cut (4.03 ± 0.45 mPa•s vs. 4.47 ± 0.36 mPa•s, t=7.122), excess inventory of red blood cells(39.75 % ± 4.09 % vs. 43.98 % ± 4.17 %, t=6.755), fibrinogen(3.21 ± 0.38 g/L vs. 4.05 ± 0.42 g/L, t=13.833) in the observation group were obviously lower than the control group after treatment (P<0.05 or P<0.01).

The combination of zhigancao decoction can obviously improve hemorheology of senile coronary heart disease. It has obvious effect with less adverse reactions, which is worth of spreading in clinic.

Coronary disease; Heart diseases; Aged; Hemorheology; Zhi Gan Cao Tang