Clinical Study
Clinical observation of elephantiasis myogenic cream for treatment of chronic refractory skin ulcer
Ma Le, Xi Jianyuan, Liu Tao, Xiao Ruifei
Published 2019-02-28
Cite as Int J Trad Chin Med, 2019, 41(2): 150-153. DOI: 10.3760/cma.j.issn.1673-4246.2019.02.011
Abstract
ObjectiveTo explore clinical efficacy of elephantiasis myogenic cream for treatment of chronic refractory skin ulcer.
MethodsA total of 91 chronic refractory skin ulcer patients were randomized into the treatment group (n=46) and the control group (n=45) by random number table method. Patients of control group were treated with conventional debridement, while the treatment group were treated with elephantiasis myogenic cream. The two groups were treated for 4 weeks. Clinical curative effect was evaluated after treatment. The pain score at the times of debridement and ulcer wound healing time of the two groups were compared. The FGF-2, VEGF and fiber connection (Fn) of wound secretion of the two groups before and after treatment were compared.
ResultsTotal effective rate of treatment group was 87.0% (40/46), which was significantly higher than the control group 66.7% (30/45), and the difference was statistically significant (χ2=5.275, P=0.022). The pain score at the time of 2 w and 4 w after treatment in the treatment group were significantly lower than those in the control group (t value were 10.456, 12.266, all Ps<0.01). After treatment, ulcer wound healing time in the treatment group were significantly lower than those in the control group (t=2.911, P=0.002). After treatment, the FGF-2 (7.72 ± 0.58 ng/ml vs. 6.37 ± 0.50 ng/ml, t=11.881), VEGF (24.85 ± 5.63 ng/ml vs. 18.75 ± 4.51 ng/ml, t=5.697) and Fn (4.15 ± 0.42 ng/ml vs. 3.47 ± 0.38 ng/ml, t=8.093) of wound secretion in the treatment group were significantly higher than those in the control group (P<0.05). There were no serious adverse reaction of the two groups during treatment.
ConclusionsThe elephantiasis myogenic cream for treatment of chronic refractory skin ulcer has a good efficacy and low adverse reactions, can relieve patients' pain, improve the wound heal, reduce heal times.
Key words:
Skin ulcer; Refractory diseases; Elephantiasis myogenic cream; Pain management; Wound healing
Contributor Information
Ma Le
Department of Dermatology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410000, China
Xi Jianyuan
Department of Dermatology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410000, China
Liu Tao
Department of Andrology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410000, China
Xiao Ruifei
Pharmacy Department, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410000, China
