To explore the complications and risk factors of CT-guided percutaneous lung biopsy, in order to decrease the incidence of complications and improve the safety.

The data of 1 324 cases receiving CT-guided percutaneous lung biopsy in Department of Respiratory and Critical Care Medicine of Fuzhou General Hospital of PLA from January 2001 to December 2016 were retrospectively analyzed.The incidence of complications such as pneumothorax, pulmonary hemorrhage and hemoptysis was statistically analyzed, and the relationship of them with age, sex, puncture depth, cutting times, lesion size, and type of puncture needle was analyzed.

1 324 cases included 963 males and 361 females, the age was 8-95 years old (middle age was 57 years old). During operation or after operation, pneumothorax immediately occurred in 337 cases (25.45%), lung tissues were compressed from 1% to 65%, three patients urgently received closed thoracic drainage.Pulmonary hemorrhage occurred in 499 cases (37.69%). Hemoptysis occurred in 122 cases (9.21%), the volume of hemoptysis was 1-100 ml.Pain in punctured site occurred in 105 patients (7.93%). Stratified analysis showed that the incidence of pneumothorax and pulmonary hemorrhage was related to puncture depth, lesion size, and type of puncture needle (χ²=5.142, 10.747, 25.887, all P<0.05;χ²=77.968, 23.993, 27.277, all P<0.05), while there was no relationship of them with age, gender, and cutting times.Age, gender, puncture depth, puncture frequency, lesion size, and type of puncture needle were not associated with hemoptysis.Pain in punctured site could be reduced by using coaxial biopsy needle.Rare complications occurred in 47 cases (3.55%), including emphysema in chest wall, pain in non-punctured site, chest distress, pneumoderma, dizziness, perspiration, numbness of arms, and hemorrhinia.Tardive complications occurred in 38 cases (2.87%), including tardive pneumothorax, hemopneumothorax, hemoptysis, blood-streaked sputum, fever and upper gastrointestinal hemorrhage.

The main complications of CT-guided percutaneous lung biopsy were pneumothorax, pulmonary hemorrhage, hemoptysis, and pain in punctured site.Most of the complications were mild, and could be cured, while some of the complications might be vital.It′s also important to pay close attention to the rare and tardive complications of CT-guided percutaneous lung biopsy which must be treated in time.

Lung; Biopsy; Complication; CT guidance