Original Article
HER2 status in gastric adenocarcinoma of Chinese: a multicenter study of 40 842 patients
Huang Dan, Li Zengshan, Fan Xiangshan, Wu Hongmei, Liu Jianping, Sun Wenyong, Li Shanshan, Hou Yinyong, Nie Xiu, Li Jun, Qin Rong, Guo Lingchuan, Xu Jinghong, Zhang Huizhong, Sun Miaomiao, Guo Qiaonan, Yang Yinghong, Liu Yanhui, Qin Yu, Zhang Lijuan, Li Jinghe, Zhang Zhihong, Gao Peng, Li Yujun, Sheng Weiqi, Cooperative Gastric Cancer Study Group of China Anti-Cancer Association Tumor Pathology Committee
Published 2018-11-08
Cite as Chin J Pathol, 2018, 47(11): 822-826. DOI: 10.3760/cma.j.issn.0529-5807.2018.11.002
Abstract
ObjectiveTo investigation HER2 status in gastric adenocarcinoma of Chinese and contributing factors to the HER2 expression.
MethodsHER2 status of 40 842 gastric adenocarcinomas and clinical data were retrospectively collected from 23 hospitals dated from 2013 to 2016. The association between HER2 positivity and clinicopathologic features was analyzed.
ResultsOf the 40 842 patients the median age was 62 years, the male female ratio was 2.6∶1.0. The rate of HER2 positivity was 8.8% (3 577/40 842). HER2 expression was related to the tissue type, tumor location, Lauren classification and tumor differentiation (P values: 0.009, 0.001, <0.01 and <0.01, respectively). Different HER2 expression status was observed between primary and recurrent tumors in 7.6% (48/635) cases. The rates of HER2 positivity ranged from 2% to 10% among different institutions. The rates of HER2 FISH amplification were dramatically different among the 23 hospitals (0-100%) with an average rate of 10% (810/8 156) in patients with HER2 IHC 2+ .
ConclusionsHER2 expression is associated with clinicopathologic characteristics. HER2 re-assessment of tumor tissue and use of in situ hybridization techniques increase HER2 positivity. The current retrospective study should reflect the HER2 status in gastric adenocarcinoma of Chinese patients.
Key words:
Stomach neoplasms; Multicenter study; Genes, erbB-2; Immunohistochemistry; In situ hybridization
Contributor Information
Huang Dan
Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China
Li Zengshan
Fan Xiangshan
Wu Hongmei
Liu Jianping
Sun Wenyong
Li Shanshan
Hou Yinyong
Nie Xiu
Li Jun
Qin Rong
Guo Lingchuan
Xu Jinghong
Zhang Huizhong
Sun Miaomiao
Guo Qiaonan
Yang Yinghong
Liu Yanhui
Qin Yu
Zhang Lijuan
Li Jinghe
Zhang Zhihong
Gao Peng
Li Yujun
Sheng Weiqi
Cooperative Gastric Cancer Study Group of China Anti-Cancer Association Tumor Pathology Committee
