Evidence-based Medicine
Clinical efficacy and safety of sodium hyaluronate gel in the prevention of intrauterine adhesions after induced abortion: a Meta-analysis
Yan Xie, Qiang Liu, Youzhen Luo, Yuanhong Zhou
Published 2018-11-25
Cite as Chin J Reprod Contracep, 2018, 38(11): 920-926. DOI: 10.3760/cma.j.issn.2096-2916.2018.11.008
Abstract
ObjectiveTo investigate the clinical effectiveness and safety of sodium hyaluronate gel in preventing intrauterine adhesion (IUA) after surgical abortion.
MethodsThe databases including Pubmed database, Springer database, Cochrane library, Elsevier ScienceDirect database, CNKI database, Wanfang database, VIP database were systematically searched to collect the randomized control trail (RCT) about sodium hyaluronate gel in preventing IUA after artificial abortion, the retrieval time is from the building of each database to December 2017. According to the inclusion and exclusion criteria to search studies, data extraction and quality assessments were performed. RevMan 5.3 software was used for Meta-analysis.
ResultsFourteen RCTs were included. Meta-analysis showed that compared with control group, the incidence of IUA and the 3 stages (mild, moderate and severe) of adhesion in experimental group were statistically lower (P<0.000 01). In experimental group, the lasting time and the amount of vaginal bleeding after operation were less, the time of menstruation turnover was shorter, the incidence of hypomenorrhea, amenorrhea and the periodic hypogastralgia was lower, and all the differences were statistically significant (P<0.000 01).
ConclusionApplication of sodium hyaluronate gel after induced abortion can reduce the incidence of IUA, moderate the severity of adhesions, promote the recovery of the uterus and reduce postoperative complications.
Key words:
Intrauterine adhesion (IUA); Sodium hyaluronate gel; Meta-analysis
Contributor Information
Yan Xie
Department of Obstetrics and Gynecology of the First Clinical Hospital of China Three Gorges University, Yichang 443000, China
Qiang Liu
Department of Obstetrics and Gynecology of the First Clinical Hospital of China Three Gorges University, Yichang 443000, China
Youzhen Luo
Department of Obstetrics and Gynecology of the First Clinical Hospital of China Three Gorges University, Yichang 443000, China
Yuanhong Zhou
Department of Obstetrics and Gynecology of the First Clinical Hospital of China Three Gorges University, Yichang 443000, China
