The appearance of proton pump inhibitors (PPIs) is a milestone in the history of treatment of digestive system diseases in the 20th century. In recent years, PPIs were used from treatment to prevention in more and more clinical departments not only in China, but also in European and American countries , and constantly expanding its' indications. The phenomenon of unreasonable application of prevention is becoming more and more serious. However, domestic and foreign guidelines and expert consensus on prophylactic application of PPIs are relatively scattered and most of them are explained from the perspective of diseases. Therefore, clinicians and pharmacists are in urgent need of a comprehensive and authoritative standard for the preventive application of PPIs. Since 2012, Affiliated Hospital of Yangzhou University has begun to comment on the rationality of application of PPIs in out-patient prescriptions and medical orders. In 2014, the hospital held National Symposium on the Rational Application of Proton Pump Inhibitors.Experts in pharmacology, gastroenterology, neurology, critical care medicine, surgery and others demonstrated three times to draft the Guidelines on the Preventive Application of Proton Pump Inhibitors. It was implemented as an internal regulation in the hospital. Three years later, it was integrated with the latest domestic and foreign authoritative literature to compose the Expert Consensus on the Preventive Application of Proton Pump Inhibitors, which is used to guide clinicians and pharmacists.

Proton pump inhibitors/PD; Gastric mucosa/DE; Chemoprevention