A follow-up study on the changes in salience network function connectivity in clinically cured patients with depression
Wang Zhenzhen, Zhong Jiaqi, Ma Hui, Teng Changjun, Han Yang, Wang Hui, Zhang Ning
Published 2020-10-05
Cite as Chin J Psychiatry, 2020, 53(5): 400-405. DOI: 10.3760/cma.j.cn113661-20200619-00286
Abstract
ObjectiveTo explore the change of salience network functional connectivity over time in patients with clinically cured depression.
MethodsTwenty-two healthy controls (control group) and 17 clinically cured depressed patients (clinically cured group) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan at baseline and 6 months later. Routine preprocessing of rs-fMRI data was performed. Salience network was extracted by independent component analysis (ICA) followed by a t-test to compare the differences of salience network functional connectivity between the control group and clinically cured patient group at both baseline and 6 months follow-up. Results were corrected by AlphaSim correction method.
ResultsAt baseline, compared to the control group, clinically cured patient group showed a significantly increased functional connectivity in the dorsolateral prefrontal cortex (t=2.84, P<0.01, AlphaSim correction) and a significantly increased functional connectivity in the medial prefrontal cortex (t=4.08, P<0.01, AlphaSim correction) as well as a decreased functional connectivity in the left precuneus (t=-3.06) and dorsolateral prefrontal cortex (t=-2.98, P<0.01, AlphaSim correction) at 6 months follow-up.
ConclusionPatient′s functional connectivity of salience network may not stable during the first 6 months after being clinically cured. The abnormal functional connectivity in the dorsolateral prefrontal cortex when they are initially and clinically cured may gradually improve.
Key words:
Depressive disorder; Magnetic resonance imaging; Salience network; Clinical cure; Functional connectivity
Contributor Information
Wang Zhenzhen
School of Psychology, Nanjing Normal University, Nanjing 210097, China
Zhong Jiaqi
School of Psychology, Nanjing Normal University, Nanjing 210097, China
Ma Hui
Department of Medical Psychology, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Teng Changjun
Department of Medical Psychology, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Han Yang
School of Psychology, Nanjing Normal University, Nanjing 210097, China
Wang Hui
Department of Medical Psychology, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Zhang Ning
Department of Medical Psychology, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
