To explore the application value of radical prostatectomy(RP) combined with extented pelvic lymph node dissection(ePLND) in patients with clinically localized prostate adenocarcinoma.

We searched the PubMed, Embase, Cochrane Library databases, the China Knowledge Network(CNKI) database, Wanfang database, Chinese Biomedical Literature Database by computer.The following MeSH terms and their combinations were searched in English and Chinese, respectively: prostate neoplasms, prostate neoplasm, prostatic neoplasm, prostate cancer, prostate cancers, cancer of the prostate, prostatic cancer, prostatic cancers, cancer of prostate, lymph node excisions, lymphadenectomy; lymphadenectomies, lymph node dissections, radical prostatectomy, extent, extented, standard, standardized, limit, limited; prostate cancer, radical prostatectomy, lymph node dissections.The search was set for all case-control studies on the comparison in patients with clinically localized prostate cancer beteeen RP with ePLND with standard (sPLND) or limited PLND(lPLND). Two authors independently screened the literature, extracted relevant literature data, and evaluated the quality of the literature.The software Revman 5.3 and Stata 12.0 were used to perform meta-analysis in this study. The software R 3.6.0 was used to combine the total survival curves. The limited template was included in the sPLND for comparison.

Fourteen studies with a total of 12, 148 patients were included.Compared with sPLND, ePLND significantly improved lymph node yield(LNY)(WMD=9.72, 95%CI 6.81-12.63, P<0.05) and the detection of more lymph node positivity of metastasis(LN+ )(RR=2.89, 95%CI 2.16-3.86, P<0.00001). ePLND increased the complication rate, but the differences were not statistically significant(RR=1.39, 95%CI 0.95-2.05, P=0.09). The ePLND group had significantly lower biochemical recurrence(BCR)(RR=0.69, 95%CI 0.52-0.91, P=0.01) and higher biochemical-free survival(HR=0.59, 95%CI 0.56-0.63, P<0.05). Meanwhile, according to the overall survival, the two groups of curves became more and more distant over time(HR=0.59, 95%CI 0.56-0.63, P<0.05).

Compared with sPLND, RP combined with ePLDN could be more effective than standard PLND in patients with clinically localized prostate cancer and provides a better prognosis.

Prostatic neoplasms; Radical prostatectomy; Lymph node dissection; Prostate cancer; Meta-analysis