Advances in fundus imaging technology have enabled transformative shifts in the diagnosis and management of intraocular tumor (such as retinoblastoma, choroidal melanoma, primary vitreoretinal lymphoma, retinal capillary hemangioma and metastatic carcinoma). With each successive improvement in ultra-widefield fundus, fluorescein fundus angiography, fundus autofluorescence and indocyanine green fundus angiography, our observations on the nature, location, and secondary lesions caused by the tumor has become increasingly rich with the additional information that multimodal imaging paradigm provides. Although there is still a lack of standards for application and diagnostic criteria and are still problems such as low resolution, pseudocolor image, warping of the retinal area and artifact, ultra-widefield imaging plays a greater role in new medical models such as clinical diagnosis and treatment and telemedicine. It is reasonable to expect that with continued technological advances in multimodal widefield imaging that our ability to capture further detail and resolution of the retina will continue to expand. Ultra-widefield will become the standard-of-care imaging modality for many diseases and find more new clinical and research applications such as for screening and telemedicine. (Int Rev Ophthalmol, 2022, 46: 85-91)