Review
Advances in magnetic resonance imaging of impulsive-compulsive behavior in Parkinson′s disease
Zhao Gaohua, Cao Lanxiao, Zhao Guohua
Published 2022-05-08
Cite as Chin J Neurol, 2022, 55(5): 544-550. DOI: 10.3760/cma.j.cn113694-20211009-00687
Abstract
Impulsive-compulsive behaviors (ICBs), one of the non-motor symptoms of Parkinson′s disease (PD), may be attributed to dopaminergic dysfunction and dopamine replacement therapy. At present, understanding of ICBs, mechanisms and exploration of treatment largely depend on neuroimaging research. Despite contradictions among the findings, most evidence indicated that PD patients with ICBs showed decreased thickness in frontal and temporal cortex and the volume of subcortical nuclei when compared to those without ICBs. And the occurrence of ICBs is associated with relatively preserved white-matter integrity in the brain regions involved in reward-related behaviors. This article will give an overview of the magnetic resonance research of PD related ICBs including cortical thickness, diffusion tensor imaging, resting state and task state functional magnetic resonance imaging analysis, which lays a foundation for further imaging studies, revealing the pathogenesis and exploring the potential treatment options.
Key words:
Parkinson disease; Impulse control disorders; Magnetic resonance imaging; Neuroimaging
Contributor Information
Zhao Gaohua
Department of Neurology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China
Cao Lanxiao
Department of Neurology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China
Zhao Guohua
Department of Neurology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China