Long tracheal injury or stenosis has always been a difficult problem to be solved in surgical reconstruction. When the resections of the diseased tissue or stenosis and end-to-end anastomosis can not achieve the clinical curative effects, tissue-engineered trachea provides a new inspiration for tracheal replacement therapy. Scaffolds provide the guarantee for the adhesion and growth of cells and the role-play of cytokines. Therefore, appropriate tracheal scaffolds are the key to the successful implementation of tissue-engineered trachea, and the selection of scaffold materials has become the important part. With the deepening of the interdisciplinary concept, biomaterials have been continuously developed and applied. Among them, polycaprolactone occupies a place in the field of scaffold materials with its unique advantages, such as good solubility, biocompatibility, biodegradability and stable mechanical properties. This paper reviews the application and prospect of polycaprolactone in tissue-engineered tracheal scaffold.