Clinical Study
Study on the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women
Huang Wenjun, Geng Lulu, Jiang Susu, Li Changbin, Tao Minfang
Published 2022-06-25
Cite as Chin J Reprod Contracep, 2022, 42(6): 589-594. DOI: 10.3760/cma.j.cn101441-20201030-00596
Abstract
ObjectiveTo evaluate the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.
MethodsA cross-sectional study was used to analyze the clinical data of 314 women who first visited the menopausal clinic of Department of Gynecology and Obstetrics of Shanghai Jiao Tong University Affiliated Sixth People's Hospital from October 2018 to October 2020. The modified Kupperman menopausal index (KMI) scale was used to assess the prevalence and severity of menopausal symptoms, and a short version of everyday cognition (ECog) scale was used to evaluate everyday cognition. Multiple linear regression was used to analyze the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.
ResultsThe ECog score of 314 patients was 1.50±0.49. The score of KMI was 12.67±7.88, 74.8% (235/314) of the patients had menopausal symptoms, and 34.7% (109/314) had moderate to severe menopausal symptoms. Compared with asymptomatic patients (ECog scores: 1.27±0.29), symptomatic patients had higher ECog scores (mild symptoms group: 1.48±0.47, P=0.005; moderate to severe symptoms group: 1.69±0.55, P<0.001). Correlation analysis showed that the five symptoms of KMI (hot flashes/sweating, insomnia, irritability, melancholia and fatigue) were associated with the decline of everyday cognition (P<0.001). Multiple linear regression analysis showed that the symptoms of hot flashes/sweating [β=0.060, 95% confidence interval (CI) =0.002-0.117, P=0.043], melancholia (β=0.163, 95% CI=0.073-0.253, P<0.001) and fatigue (β=0.138, 95% CI=0.071-0.205, P<0.001) were still associated with the decline of everyday cognition.
ConclusionThe symptoms of hot flashes/sweating, melancholia and fatigue are independent risk factors for the decline of everyday cognition in perimenopausal and postmenopausal women.
Key words:
Perimenopause; Menopausal symptoms; Everyday cognition; Relationship
Contributor Information
Huang Wenjun
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China
Geng Lulu
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China
Jiang Susu
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China
Li Changbin
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China
Tao Minfang
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200030, China
