Review
Role of group 2 innate lymphoid cells in viral infectious diseases
Ding Huimin, Lu Zhenyu, Li Yuan, Wang Ying, Jia Peifeng, Gao Xiaoyu, Yun Chunmei
Published 2022-08-30
Cite as Chinese J Exp Clin Virol, 2022, 36(4): 481-487. DOI: 10.3760/cma.j.cn112866-20211229-00216
Abstract
Group 2 innate lymphoid cells (ILC2s) are novel innate immune cells. Similar to T cells, ILC2s can secrete Th2 cytokines and initiate and maintain type 2 immune responses, which are also named as cross-border immune cells between innate immunity and adaptive immunity. In recent years, infectious diseases caused by pathogenic viruses have become a global healthcare challenge with the outbreaks of Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and novel coronavirus disease 2019 (COVID-19). As a member of the innate lymphocyte family, ILC2s are involved in the development of group 2 inflammatory diseases and can activate immune activity, playing an essential role in the repair of tissue damage and in the body’s defense, which also can participate in the immune response and play an important role in viral immunity when a virus attacks on the body. This study reviews the defensive role of ILC2s in viral infections, providing a theoretical basis for elaborating the role of ILC2s in viral infectious diseases.
Key words:
Group 2 innate lymphoid cells; Virus infection; Immune; Inflammatory
Contributor Information
Ding Huimin
Inner Mongolia Medical University, Hohhot 010059, China
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Lu Zhenyu
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Li Yuan
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Wang Ying
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Jia Peifeng
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Gao Xiaoyu
State Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease, Key Laboratory of Respiratory Diseases in Inner Mongolia Autonomous Region, Hohhot 010017, China
Yun Chunmei
Inner Mongolia Medical University, Hohhot 010059, China
