Clinical characteristics of adult Chinese patients with syncope: a multicenter clinical study
Yang Fengjing, Li Xu, Liang Peng, Liu Zhongmei, Liu Tong, Wu Yun, Xin Shuanli, Zhang Gaoxing, Yan Shilin, Xu Lingping, Wang Lixin, Hu Bo, Yue Wenwei, Pu Jielin, Huang Zhichun, Wang Rui, Wen Wen, Lin Peihong, Li Li, Yu Zaixin, Wang Xiaodong, Liu Xijiu, Adila·Azhati, Zhang Jie, Qu Xiufen, TSE Gary, Pan Yikun, Hong Kui, Zhu Jieming, Li Lihua, Pan Wen, Wu Yong, Wang Min, Song Changjun, Wang Zengshuai, Dong Jianting, Yang Xinchun, Hu Xitian, Wang Fujun, Liu Wenling
Abstract
ObjectiveTo analyze the clinical characteristics of adult Chinese patients with syncope.
MethodsThis is a cross-sectional survey study. Patients with preliminary diagnosis of syncope in the Emergency Department, Geriatrics and Cardiology Outpatient Department, or Syncope Unit of 37 hospitals in 19 provinces, autonomous regions and the Hong Kong Special Administrative Region from June 2018 to March 2021 were included in this study. The clinical features of these patients with syncope were analyzed.
ResultsA total of 4 950 consecutive patients with syncope were included in this study. The age was (56.3±16.8)years, and 2 604 cases (52.6%) were male. The most common type of syncope was neurally mediated syncope (2 345 (47.4%)), followed by cardiac syncope (1 085 (21.9%)), orthostatic hypotensive syncope (311 (6.3%)), and unexplained syncope accounted for nearly one third (1 155 (23.3%)). Predisposing syncope was more common in patients under 65 years of age(2 066(72.4%) vs. 786(27.6%),χ2=136.5,P<0.001). Presyncope was more common in patients with neurally mediated syncope (1 972(79.0%) vs.1 908(73.9%), χ2=17.756, P<0.001). Premonitory symptoms were more common in women(1 837(80.0%) vs. 1 863(73.0%),χ2=33.432,P<0.001). Presyncope syndrome was more common in patients under 65 years of age (2 482(77.8%) vs. 1 218(73.4%),χ2=17.523,P=0.001). Cyanosis was more common in ≥65 years old patients (271(18.2%) vs. 369(12.7%), χ2=23.235, P<0.001). Urinary incontinence was more common in old patients aged ≥65 years(252(15.2%) vs. 345(10.8%), χ2=19.313, P<0.001). Family history was more common in patients with cardiogenic syncope compared with other types of syncope (264(24.3%) vs. 754(19.5%), χ2=11.899, P=0.001). Hypertention(1 480(30.5%)), coronary heart disease(1 057(21.4%)), atrial flutter and atrial fibrillation(359(7.2%)), second degree atrioventricular block(236(4.8%)) were common complications of syncope. The proportion of patients with coronary heart disease was significantly higher in cardiac syncope than that of other types of syncope(417(38.4%) vs. 640(16.6%), χ2=241.376, P<0.001). Other common complications included cerebrovascular diseases (551 (11.1%)) and diabetes mellitus (632(12.8%)).
ConclusionsNeurally mediated syncope is the most common syncope in adult Chinese population. Patients with predisposing conditions and premonitory conditions are younger. Presyncope is more common in women. The proportion of family history and coronary heart disease is higher in patients with cardiogenic syncope.
Key words:
Syncope; Adult; Clinical characteristics
Contributor Information
Yang Fengjing
Department of Cardiology, Peking University People′s Hospital, Beijing 100044, China
Li Xu
Department of Cardiology, Peking University People′s Hospital, Beijing 100044, China
Liang Peng
Department of Cardiology, Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing 100021, China
Liu Zhongmei
Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming 650031, China
Liu Tong
Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
Wu Yun
Department of Cardiology, Inner Mongolia Autonomous Region People′s Hospital, Hohhot 010017, China
Xin Shuanli
Department of Cardiology, Handan First Hospital, Handan 056000,China
Zhang Gaoxing
Department of Cardiology, Jiangmen Central Hospital, Jiangmen 529000, China
Yan Shilin
Department of Cardiology, Yangling Demonstration Zone Hospital, Xianyang 712100, China
Xu Lingping
Department of Cardiology, Xianyang Center Hospital, Xianyang 712000, China
Wang Lixin
Department of Cardiology, Cangzhou Hospital of Traditional Chinese and Western Medicine in Hebei Province, Cangzhou 061013, China
Hu Bo
Department of Emergency Center, Shandong Provincial Hospital, Jinan 250021, China
Yue Wenwei
Department of Cardiology, Fourth People′s Hospital, Jinan 250031,China
Pu Jielin
Department of Cardiology, East Hospital, Tongji University, Shanghai 200120, China
Huang Zhichun
Department of Cardiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
Wang Rui
Department of Cardiology, People′s Hospital of Yuxi City, Yuxi 653100, China
Wen Wen
Cardio-Pulmonary Function Department, Zhengzhou Central Hospital of Zhengzhou University, Zhengzhou 450007, China
Lin Peihong
Emergency Department, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China
Li Li
Department of Cardiology, Cilin Hospital, Cixi 315315, China
Yu Zaixin
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China
Wang Xiaodong
Functional Laboratory Department, Second People′s Hospital of Nanyang City, Nanyang 473012, China
Liu Xijiu
Department of Medicine, Wangkui Traditional Chinese Medicine Hospital, Suihua 152199, China
Adila·Azhati
Department of Emergency Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
Zhang Jie
Department of Neurology, First Hospital of Jilin University, Changchun 130021, China
Qu Xiufen
Department of Cardiology, First Afiliated Hospital of Harbin Medical University,Harbin 150001,China
TSE Gary
Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, China-UK Collaboration, Kent and Medway Medical School, Hong Kong 999077, China
Pan Yikun
Functional Department, People′s Hospital of Dali Bai Autonomous Prefecture,Dali 671000,China
Hong Kui
Department of Cardiology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
Zhu Jieming
Department of Cardiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
Li Lihua
Department of Cardiology, Tianjin Chest Hospital, Tianjin 300051, China
Pan Wen
Emergency Department, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000,China
Wu Yong
Department of Cardiac Function, Affiliated Hospital of Yangzhou University, Yangzhou 225009, China
Wang Min
Department of Cardiology, Bozhou People′s Hospital, Bozhou 236803, China
Song Changjun
Department of Neurology, Shaanxi Sengong Hospital, Xi′an 710300, China
Wang Zengshuai
Department of Cardiology, Second Affiliated Hospital of Baotou Medical College, Baotou 014030, China
Dong Jianting
Department of Cardiology, Zhongshan People′s Hospital, Zhongshan 528400, China
Yang Xinchun
Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Hu Xitian
Department of Cardiology, First Hospital of Shijiazhuang, Shijiazhuang 050091, China
Wang Fujun
Department of Cardiology, People′s Hospital of Western Hunan Tujia and Miao Nationality Autonomous Region, Medical College of Jishou University, Jishou 416000, China
Liu Wenling
Department of Cardiology, Peking University People′s Hospital, Beijing 100044, China
