With the help of assisted reproductive technologies (ART), many infertile couples fulfil their wish to have a child. The health of these offspring attracts growing attention as the proportion of ART births rises. Early-life developmental plasticity connects environmental influences to individual growth and disease susceptibility, epigenetics may be the mechanism. Since cardiovascular disease (CVD) is the primary threat to human health, the impact of ART on the cardiovascular health of offspring is of great importance. This paper reviews the cardiovascular health indicators of ART offspring, the effects and potential mechanisms arising from several techniques and procedures of ART, parental factors, intrauterine environment and growth patterns. This review will aid clinicians and embryologists in better understanding and focusing on the safety of ART technology, promoting the optimization of technology and treatment processes, and further securing and improving the health of patients.

Reproductive techniques, assisted; Cardiovascular diseases; Epigenomics; Fertilization in vitro; Embryo transfer; Sperm injections, intracytoplasmic; Preimplantation diagnosis; Pregnancy, multiple