Original Article
Correlation study of serum creatinine/cystatin C and sarcopenia
Ma Sihui, Zhang Xiangyu, Chen Lin
Published 2023-09-14
Cite as Chin J Geriatr, 2023, 42(9): 1083-1088. DOI: 10.3760/cma.j.issn.0254-9026.2023.09.011
Abstract
ObjectiveTo explore the correlation between serum creatinine/cystatin C(Scr/CysC)ratio and sarcopenia, and search for serum markers specific to sarcopenia.
MethodsA retrospective case-control study of 142 hospitalized patients in the Department of Geriatrics, Xiangya Second Hospital, Central South University from November 2020 to February 2022 were collected, including 43 sarcopenia cases and 99 non sarcopenia cases.The correlation between Scr/CysC ratio and sarcopenia was analyzed and explored.
ResultsThe Scr/CysC ratio of 71.5±12.5 in the sarcopenia group was significantly lower than that of 81.9±15.8 in the non-sarcopenia group(t=3.823, P<0.001), and Scr/CysC was positively correlated with muscle mass and grip strength(r=0.52, 0.69, both P<0.001).The results of the analysis of receiver operating characteristic curves of the subjects showed that in male inpatients, the area under the curve(AUC)of the Scr/CysC ratio in the diagnosis of sarcopenia was 0.770(95%CI: 0.655 to 0.886, P<0.001), with a diagnostic reference value of 80.97, which gave a sensitivity of 72.2% and a specificity of 68.4%.In female inpatients the AUC was 0.621(95%CI: 0.474 to 0.768, P=0.099), with a diagnostic reference value of 65.20, giving a sensitivity of 77.8% and a specificity of 58.3%.
ConclusionsThe serum Scr/CysC ratio may be a serum marker for male sarcopenia patients, and sarcopenia may be considered when it is below 80.97; The diagnostic value in female sarcopenia needs further research.
Key words:
Biological markers; Hand strength; Sarcopenia; Serum creatinine/cystatin C
Contributor Information
Ma Sihui
Geriatrics Department, Institute of Aging and Geriatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, China
Department of Geriatrics, the Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, China
Zhang Xiangyu
Geriatrics Department, Institute of Aging and Geriatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, China
Chen Lin
Geriatrics Department, Institute of Aging and Geriatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, China
