The placenta is the site of material exchange and barrier between mother and the offspring, plays a crucial role in the growth of fetus. Dysfunction of placenta is responsible for varies of adverse pregnancy outcome. Current in vitro experimental models of the placenta all have their limitations and are insufficient for research. Recently, organoid and organ-on-a-chip technology develop rapidly, and provide a potentially powerful approach to drug discovery and basic medical research. Organoids derived from human placenta closely resemble origin trophoblast in cell phenotype, genetic expression and so on. Placenta organ-on-a-chip mimics the placenta barrier and has been used in research of drug transport across the placenta. Establishment of placenta organoid-on-a-chip, or multi-organ chip contains placenta and endometrium cells can be a potential direction of research in the future.

Organoid; Organ-on-a-chip; Placental barrier; In vitro model