To summarize the best evidence for the prevention and nursing of immune checkpoint inhibitor (ICI) associated skin toxicity in lung cancer patients, providing reference for clinical and nursing staff.

Evidence-based nursing issues were constructed using the population, intervention, professional, outcome, setting and type of evidence (PIPOST) model of the Joanna Briggs Institute Evidence Based Health Care Center. The "6S" pyramid model was used to search for guidelines, expert consensus, systematic reviews, best practices, evidence summary, and original research on the prevention and nursing of ICI associated skin toxicity in lung cancer patients from top to bottom in domestic and foreign databases, professional association websites, and guideline websites. Articles that met the inclusion criteria was screened, evaluated for quality, and evidence was extracted. The search period was from the establishment of the database to October 1, 2022.

A total of 14 articles were included, involving 6 expert consensuses, 5 guidelines, and 3 systematic reviews. A total of 24 best evidences were summarized from 7 aspects, including high-risk factors, baseline screening, immune checkpoint inhibitors (ICIs) treatment monitoring, daily skin nursing, multidisciplinary management, symptom management, and health education.

Medical and nursing staff should combine clinical situations, consider the needs and preferences of patients, and use the best evidence to develop scientific and personalized nursing plans to reduce the occurrence of ICI associated skin toxicity.

Lung neoplasms; Immune checkpoint inhibitors; Dermal toxicity; Evidence-based nursing; Evidence summary