The high incidence of liver metastasis in pancreatic cancer is the main reason for its refractoriness. In recent years, with the improvement of surgical techniques, gene testing, and comprehensive treatment, many progress has been made in liver metastasis of pancreatic cancer. Individualized assessment prior to treatment is an important basis for developing an individualized treatment program. A specific proportion of patients with oligo-metastatic pancreatic cancer could achieve a good prognosis with surgical treatment, while the patients with higher metastatic load should receive both local and comprehensive treatment to prolong the overall survival. More evidence-based medical evidence is needed to guide the management of liver metastasis of pancreatic cancer in the future. In this paper, we provide a systematic review of recent advances in treatment of liver metastasis of pancreatic cancer with the combination of the latest research findings at home and abroad and our clinical practice experience.

Pancreatic cancer; Liver metastasis; Surgical therapy; Comprehensive therapy