Review
Progress in the clinical cure of the population of inactive hepatitis B surface antigen carriers
Mo Zhishuo, Gao Zhiliang
Published 2023-12-20
Cite as Chin J Hepatol, 2023, 31(12): 1336-1339. DOI: 10.3760/cma.j.cn501113-20231116-00201
Abstract
The population of inactive HBsAg carriers (IHCs) is enormous, and it is often overlooked because of the insidious progression and mild severity of the disease. With the continuous enrichment and consolidation of research evidence, the population of IHC has obtained a high clinical cure rate through a treatment strategy based on pegylated interferon α and a stronger treatment intention. This article reviews the definition and treatment recommendations of IHCs in current domestic and international guidelines, as well as the disease progression and clinical cure research progress, so as to provide a reference and basis for scientific management and rational therapeutics.
Key words:
Hepatitis B surface antigen; Inactive hepatitis B surface antigen carriers; Disease progression; Pegylated interferon alpha; Clinical cure; HBsAg clearance
Contributor Information
Mo Zhishuo
Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
Gao Zhiliang
Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China