Association between visceral fat area measured with quantitative CT and fatty liver in normal weight population
Qiao Qi, Zhou Yang, Sun Yongbing, Qi Xin, Du Yawei, Li Zhonglin, Zou Zhi, Wu Xiaoling, Zhou Jing, Zhang Gong, Qu Min, Zhang Xiaolin, Wang Yong, Dou Shewei, Liu Hongming, Yan Fengshan, Zhu Jiadong, Li Yongli
Abstract
ObjectiveTo analyze the association between visceral fat area (VFA) and fatty liver based on quantitative CT (QCT) in people receiving health examination with normal body mass index (BMI).
MethodsA cross-sectional study. A total of 1 305 physical examiners who underwent chest CT and QCT examination in the Department of Health Management of Henan Provincial People′s Hospital from January to December 2021 were retrospectively selected as subjects. The physical components at the central level of the lumbar two cone were measured with QCT, including subcutaneous fat area (SFA), VFA and liver fat content (LFC). And the metabolic indexes, such as blood lipids and blood glucose, were collected. The t-test and χ2 test were used to analyze the correlation between the detection rate of fatty live and LFCr and age and gender. According to level of VFA (<100 cm2, 100-150 cm2 and≥150 cm2), the subjects were divided into three groups, and one-way ANOVA and χ2 test were used in comparison between groups. Multiple linear regression was used to analyze the correlation between VFA and metabolic indexes and LFC.
ResultsOf the 1 305 subjects, there were 634 males and 671 females. The detection rate of fatty liver in normal BMI population was 65.67%, and it was 72.71% and 59.02% respectively in men and women (χ2=27.12, P<0.001), and the detection rate of fatty liver and LFC increased with age (both P<0.05). With the increase of VFA, the age, BMI, SFA, LFC, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), alanine aminotransferase (ALT), blood uric acid and prevalence of fatty liver increased (all P<0.05), and the low-density lipoprotein cholesterol (HDL-C) decreased (P<0.001). Multiple linear regression analysis showed that after adjustment for age factors, regardless of male or female, LFC was independently positively related with VFA, BMI, and ALT (male β=0.206, 0.145, 0.174, female β=0.194, 0.150, 0.184; all P<0.05). FBG was positively correlated with male independently (β=0.134; P<0.001). The indicators related to female independently were TC, TG, and blood uric acid (β=-0.121, 0.145, 0.141, all P<0.05)
ConclusionIn the population receiving health examination with normal BMI, the VFA measured by QCT technique is closely related to fatty liver.
Key words:
Body mass index; Obesity; Fatty liver; Blood biochemical index; Correlation analysis; Quantitative CT
Contributor Information
Qiao Qi
Department of Medical Imaging, Zhengzhou University People′s Hospital, Henan Provincial People′s Hospital, Zhengzhou 450003, China
Zhou Yang
Department of Medical Imaging, Zhengzhou University People′s Hospital, Henan Provincial People′s Hospital, Zhengzhou 450003, China
Sun Yongbing
Department of Medical Imaging, Zhengzhou University People′s Hospital, Henan Provincial People′s Hospital, Zhengzhou 450003, China
Qi Xin
Department of Medical Imaging, Xinxiang Medical University, Henan Provincial People′s Hospital, Zhengzhou 450003, China
Du Yawei
Department of Medical Imaging, Henan University People′s Hospital,Henan Provincial People′s Hospital, Zhengzhou 450003, China
Li Zhonglin
Henan Provincial People′s Hospital Medical Imaging Department, Zhengzhou University People′s Hospital, Henan University People ′s Hospital, Zhengzhou 450003, China
Zou Zhi
Henan Provincial People′s Hospital Medical Imaging Department, Zhengzhou University People′s Hospital, Henan University People ′s Hospital, Zhengzhou 450003, China
Wu Xiaoling
Department of Nuclear Medicine, Henan Provincial People′s Hospital, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Zhou Jing
Health Management Discipline of Henan Provincial People′s Hospital, Henan Provincial Key Laboratory of Chronic Disease Health Management, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Zhang Gong
Sino-Canadian Health Engineering Research Institute, Canada Sevenoaks Wellness Institute, Hefei 230088, China
Qu Min
Health Management Discipline of Henan Provincial People′s Hospital, Henan Provincial Key Laboratory of Chronic Disease Health Management, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Zhang Xiaolin
Health Management Discipline of Henan Provincial People′s Hospital, Henan Provincial Key Laboratory of Chronic Disease Health Management, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Wang Yong
General medicine in Henan Provincial People′s Hospital, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Dou Shewei
Henan Provincial People′s Hospital Medical Imaging Department, Zhengzhou University People′s Hospital, Henan University People ′s Hospital, Zhengzhou 450003, China
Liu Hongming
Henan Provincial People′s Hospital Medical Imaging Department, Zhengzhou University People′s Hospital, Henan University People ′s Hospital, Zhengzhou 450003, China
Yan Fengshan
Henan Provincial People′s Hospital Medical Imaging Department, Zhengzhou University People′s Hospital, Henan University People ′s Hospital, Zhengzhou 450003, China
Zhu Jiadong
Health Management Discipline of Henan Provincial People′s Hospital, Henan Provincial Key Laboratory of Chronic Disease Health Management, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
Li Yongli
Health Management Discipline of Henan Provincial People′s Hospital, Henan Provincial Key Laboratory of Chronic Disease Health Management, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China
