Research on Bone Metabolism
Association of hemoglobin levels with bone mineral density and osteoporosis in patents with type 2 diabetes
Tan Juan, Liu Yuanyuan, Zhu Yongfang, Li Hong, Song Yingjian
Published 2024-02-25
Cite as Chin J Endocrinol Metab, 2024, 40(2): 98-103. DOI: 10.3760/cma.j.cn311282-20231018-00120
Abstract
ObjectiveTo explore the association of hemoglobin(HGB) levels with bone mineral density(BMD) and osteoporosis in patients with type 2 diabetes mellitus(T2DM).
MethodsA cross-sectional study was conducted in 364 patients with T2DM who were hospitalized in the Department of Endocrinology and Geriatrics of the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University from September 2019 to September 2020. Participants were stratified into tertiles(lower, middle, and upper) according to femoral BMD determined by dual-energy X-ray absorptiometry. Demographic characteristics, medical history, chronic diabetes complications, and comorbid conditions were compared among the 3 groups. The association between hemoglobin levels and BMD/osteoporosis was examined using multivariable logistic regression analyses. Interaction and stratified analyses were conducted according to age, body mass index(BMI), duration of diabetes, estimated glomerular filtration rate(eGFR), glycosylated hemoglobin(HbA1C), total cholesterol(TC), triglycerides(TG), high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C) and uric acid(UA).
ResultsAfter adjusting for age, BMI, and duration of diabetes, there were no significant differences observed in the association between hemoglobin levels and BMD or osteoporosis among postmenopausal women with T2DM(all P>0.05). After adjusting for age, BMI, duration of diabetes, and eGFR, men aged≥50 years with hemoglobin≥130 g/L showed a positive association between hemoglobin level and femoral neck BMD compared to those with hemoglobin<130 g/L(β=0.057, 95%CI 0.014-0.100, P=0.011). However, no significant associations were observed between hemoglobin level and BMDs at the total hip or lumbar spine(L1-L4), nor the risk of osteoporosis(all P>0.05). Stratified analyses revealed no significant differences in the subgroups classified based on age, BMI, diabetes duration, eGFR, HbA1C, TC, TG, HDL-C, LDL-C, and UA(all interaction P>0.05).
ConclusionIn males aged 50 and above with T2DM, elevated hemoglobin levels may be a protective factor for femoral neck bone density.
Key words:
Hemoglobin; Anemia; Diabetes mellitus, type 2; Bone mineral density; Osteoporosis
Contributor Information
Tan Juan
Department of General Practice, the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
Liu Yuanyuan
Department of Endocrinology, the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
Zhu Yongfang
Department of General Practice, the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
Li Hong
Department of Health Management Center, the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
Song Yingjian
Department of Respiratory and Critical Care Medicine, the Affiliated Huaian No. 1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
