With enhanced recovery after surgery (ERAS), research and application of knee revision protheses and customized components or prostheses in the past decade, revision of total knee arthroplasty (TKA) is developing rapidly. However, periprosthetic joint infection (PJI) has always been a major clinical challenge. A comprehensive preoperative examination to find any potential infection sites should be conducted. The overall condition of the patients should be improved. Surgeons should evaluate the classification and degree of soft tissue and bone defects comprehensively and carefully select appropriate surgical approaches, bone reconstruction strategies, and revision prostheses to ultimately restore the alignment, stability, and the range of motion of the knee joint. In the future, efforts should be made to build a team of experts for the support of revisions of TKAs, including preoperative planning, 3D printing, surgical techniques, and ERAS. Nevertheless, primary TKAs protocols should always be firmly sticked to, which are a key to a low rate of revision surgeries. Prevention of PJIs and periprosthetic fractures, as well as establishing a high-quality follow-up system are of the same importance.

Periprosthetic fracture; Prosthesis-related infections; Enhanced recovery after surgery; Knee joint revision