Original Article
Predictive value of hemoglobin glycation index and monocyte to high-density lipoprotein-cholesterol ratio in type 2 diabetes mellitus with cerebral small vessel disease
Xue Hui, Deng Xu, Li Ying, Liu Tingting, Ge Jian, Han Yuanyuan
Published 2024-03-20
Cite as Chin J Diabetes Mellitus, 2024, 16(3): 314-320. DOI: 10.3760/cma.j.cn115791-20230918-00171
Abstract
ObjectiveTo explore the predictive value of hemoglobin glycation index (HGI) and monocyte to high-density lipoprotein-cholesterol ratio (MHR) in type 2 diabetes mellitus (T2DM) with cerebral small vessel disease (CSVD).
MethodsThis was a cross-sectional study. Patients with T2DM who were hospitalized in the Department of Endocrinology and Department of Neurology of Suqian First Hospital from January 2020 to December 2022 were enrolled as the subjects. Patients were divided into T2DM alone group and T2DM with CSVD group according to whether they were combined with CSVD. Monocyte counts, high-density lipoprotein-cholesterol (HDL-C), glycated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG) were collected, and MHR and HGI were calculated. Two independent sample t test, the Mann-Whitney U test, or the χ2 test were used for the comparisons between the two groups. Spearman correlation was used to analyze the correlation between HGI and MHR and T2DM with CSVD. Multivariate logistic regression analysis was used to determine the influencing factors of T2DM with CSVD. Receiver operating characteristic (ROC) curve was used to assess the diagnostic value of HGI and MHR for T2DM with CSVD.
ResultsA total of 361 patients with T2DM were included. There were 170 patients in the T2DM alone group and 191 patients in the T2DM with CSVD group. Compared with T2DM alone, patients in T2DM with CSVD group had higher MHR and HGI (P<0.001). Spearman correlation analysis showed that both HGI (r=0.196, P<0.001) and MHR (r=0.349, P<0.001) were positively correlated with T2DM and CSVD. Multivariate logistic regression analysis showed that both HGI (OR=1.314, 95%CI 1.052-1.642, P=0.016) and MHR (OR=1.056, 95%CI 1.039-1.073, P<0.001) were the influencing factors of T2DM with CVSD. The results of ROC curve analysis showed that the areas under the HGI and MHR were 0.613 (95%CI 0.555-0.671, P<0.001) and 0.702 (95%CI 0.649-0.755, P<0.001), respectively. The area under the curve predicted by HGI and MHR was 0.729 (95%CI 0.678-0.780, P<0.001).
ConclusionHGI and MHR are closely related to the onset of CSVD in T2DM patients, and have certain value in predicting T2DM with CSVD, their combined diagnostic value is higher.
Key words:
Diabetes mellitus, type 2; Cerebral small vessel disease; Hemoglobin glycation index; Monocyte to high-density lipoprotein-cholesterol ratio
Contributor Information
Xue Hui
Department of Endocrinology, Suqian First Hospital, Suqian 223800, China
Deng Xu
Department of Endocrinology, Suqian First Hospital, Suqian 223800, China
Li Ying
Department of Endocrinology, Suqian First Hospital, Suqian 223800, China
Liu Tingting
Department of Neurology, Suqian First Hospital, Suqian 223800, China
Ge Jian
Department of Neurology, Suqian First Hospital, Suqian 223800, China
Han Yuanyuan
Department of Neurology, Suqian First Hospital, Suqian 223800, China
