To retrieve, obtain and summarize the best evidence for ulcer prevention in high-risk patients with diabetic foot, so as to provide reference for clinical medical and nursing staff.

According to the "6S" pyramid model of evidence-based resources, the literature on ulcer prevention in high-risk patients with diabetic foot was systematically searched in British Medical Journal (BMJ) Best Practice, UpToDate, Joanna Briggs Institute (JBI) Evidence-Based Health Care Center Database, National Institute for Health and Clinical Excellence, Scottish Intercollegiate Guidelines Network, Registered Nurses' Association of Ontario, Medlive, Guidelines International Network, International Working Group on the Diabetic Foot, International Diabetes Federation, American Diabetes Association, Australian Diabetic Foot Network, Cochrane Library, PubMed, Embase, China Biomedical Database, China National Knowledge Infrastructure and Wanfang Data. The search period is from database establishment to September 30, 2023. Two researchers independently evaluated the included literature and extracted literature that met quality standards.

A total of 15 articles were included, including 7 guidelines, two expert consensus, one clinical practice, and five systematic reviews. This paper summarized 21 best pieces of evidence from five aspects of regular screening, self-monitoring, foot care, exercise prevention and health education for high-risk patients with diabetic foot.

The best evidence of ulcer prevention in high-risk patients with diabetic foot summarized provides evidence-based basis for clinical nursing practice.

Diabetic foot; High risk diabetic foot; Ulcer prevention; Best evidence summary; Evidence-based nursing