Analysis on disease burden of digestive system cancers in population in China
Lyu Zhangyan, Li Wenxuan, Si Guojin, Zhang Yacong, Xing Mengbo, Huang Yubei, Liu Ben, Song Fangfang, Song Fengju, Chen Kexin
Abstract
ObjectiveTo explore the incidence and mortality of digestive system cancers, and the trend of the disease burden attributed to different risk factors in population in China.
MethodsData were obtained from the GLOBOCAN 2020 and the Global Burden of Disease Study in 2019 databases and only the data from the Chinese population were included. Using Excel 2019 and R 4.2.1 software, indicators including age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life year (DALY) rate and its rate of change were used to illustrate the disease burden of digestive system cancers attributed to different factors and their trends.
ResultsIn 2020, the ASIR of digestive system cancers in China was 83.00/100 000, and the ASMR was 63.80/100 000. The numbers of digestive system cancer cases and deaths increased with age, and more cases and deaths occurred in men than in women in all age groups. The age-standardized DALY rate of esophageal cancer, gastric cancer and liver cancers showed decreasing trends in China from 1990 to 2019 (rate of change: -45.26%, -46.87%, and -65.63%, respectively), whereas the age-standardized DALY rate of pancreatic cancer, colorectal cancer and gallbladder and biliary tract cancer showed increasing trends (rate of change: 67.61%, 30.52%, and 7.21%, respectively). The trend of the mortality rate was consistent with the DALY rate. Compared with the age-standardized DALY rate attributed to behavioral factors, the annual proportion of the age-standardized DALY rate attributed to metabolic factors to the total age-standardized DALY rate of esophageal cancer, liver cancer, pancreatic cancer, and colorectal cancer increased from 1990 to 2019. There was no significant change in the rank of age-standardized DALY rate of gastric cancer, liver cancer, pancreatic cancer, and gallbladder and biliary tract cancer attributed to different risk factors in China from 1990 to 2019, but the rank of certain attributed risk factors for the age-standardized DALY rate of esophageal cancer and colorectal cancer moved ahead (esophageal cancer: high BMI; colorectal cancer: low milk intake, and low whole-grain intake).
ConclusionsThe incidence and mortality of digestive system cancers was serious in China in 2020, and the annual proportion of the disease burden of digestive system cancers attributed to metabolic factors increased from 1990 to 2019. The rank of attributed risk factors for several digestive system cancers changed significantly.
Key words:
Cancer; Digestive system; Mortality; Disability-adjusted life years; Risk factors
Contributor Information
Lyu Zhangyan
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Li Wenxuan
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Si Guojin
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Zhang Yacong
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Xing Mengbo
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Huang Yubei
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Liu Ben
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Song Fangfang
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Song Fengju
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
Chen Kexin
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
