Review
3D bioprinting of skin: advances in research and application
Chen Weiyu, Tao Juan
Published 2024-06-18
Cite as Digit Med Health, 2024, 02(3): 173-178. DOI: 10.3760/cma.j.cn101909-20240202-00019
Abstract
Three-dimensional (3D) bioprinting enables the fabrication of targeted tissue structures by layer-by-layer deposition of cell-containing bioinks. This technology finds diverse applications in the field of biomedicine. In this review, we begin by examining current categories of 3D bioprinting techniques. We then provide an overview of the current research and applications of bioprinting in the realm of skin. Specifically, we delve into the advancements of 3D bioprinted skin in research, encompassing skin physiology and skin disease modeling, and its utilization in clinical domains such as regenerative medicine, cosmetics, drug screening, and topical drug delivery.Despite its great potential, further development of bioink materials and current bioprinting technology is still needed to improve the functionalities of the printed skin structures. By integrating with machine learning, this technology could take personalised therapies and complex tissue fabrication to unprecedented levels in the future, advancing the development of skin tissue engineering and regenerative medicine.
Key words:
Skin; 3D bioprinting; Tissue engineering
Contributor Information
Chen Weiyu
Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Tao Juan
Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China