Sun Jiayi, Wang Zejie, Yu Jinyao, Zhang Yanni, Duan Yuxin, Bai Yi, Li Ling, Ye Qifa
Abstract
Acute kidney injury (AKI) is a common and severe clinical renal syndrome caused by various physiological and pathological factors, which is mainly characterized by acute transient renal function reduction. Its morbidity and mortality are high, and effective clinical treatment strategies are limited. There is increasing evidence that ferroptosis, as an iron-dependent and non-apoptotic regulated cell death caused by lipid peroxidation, is characterized by iron overload, reactive oxygen species accumulation and lipid peroxidation. It plays an important role in AKI caused by rhabdomyolysis, sepsis, ischemia reperfusion injury and the use of nephrotoxic drugs. This paper aims to summarize and extend the inducing mechanism and the defense mechanism of ferroptosis as well as its pathways involved in AKI, so as to provide a theoretical basis for subsequent relevant studies.
Key words:
Acute kidney injury; Ferroptosis; Lipid peroxidation; Ischemia reperfusion
Contributor Information
Sun Jiayi
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Wang Zejie
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Yu Jinyao
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Zhang Yanni
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Duan Yuxin
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Bai Yi
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Li Ling
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
Ye Qifa
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
The 3rd Xiangya Hospital of Central South University, Research National Health Commission on Transplantation Medicine Engineering and Technology, Changsha 410013, China
