Review
Research progress on the ionizing radiation-induced mutational signatures
Wang Ting, Yu Sutong, Li Jie, Guo Yihan, Yu Jiahua
Published 2024-07-25
Cite as Chin J Radiol Med Prot, 2024, 44(7): 628-632. DOI: 10.3760/cma.j.cn112271-20231123-00185
Abstract
In the past decade, high-throughput sequencing technologies have generated a massive amount of genomic mutation data. The interpretation of mutation data from tumor samples has revealed mutational features highly associated with carcinogenic factors, which are referred to as mutational signatures. These mutational signatures enable the assessment of the contribution rates of various carcinogenic factors during the multi-stage development of tumors. Ionizing radiation-induced gene mutations constitute the molecular basis for its carcinogenic effects. Clarifying the patterns of mutational signatures induced by ionizing radiation is of great importance for a profound understanding of stochastic effects. This review presents the research history and analytical method of mutational signatures as well as a comprehensive summary of the current status of research on mutational signatures induced by ionizing radiation. The future development of this field is also discussed.
Key words:
Ionizing radiation; Mutation; Mutational signature; Tumor
Contributor Information
Wang Ting
School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
Yu Sutong
School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
Li Jie
School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
Guo Yihan
School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
Yu Jiahua
School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
