Original Article
Characteristics and pathophysiology of simple liver cysts in Beijing
Gu Liguo, Zheng Yamin, Gao Xiang, Cai Jie, Huang Yue, Zhou Zhen
Published 2024-08-15
Cite as Int J Surg, 2024, 51(8): 528-534. DOI: 10.3760/cma.j.cn115396-20240614-00185
Abstract
ObjectiveTo explore the onset characteristics and pathophysiological changes of simple liver cyst in Beijing.
MethodsA retrospective cohort study was used. The physical examination data of Department of Health Management of Xuanwu Hospital of Capital Medical University for 10 years from January 1, 2012 to December 31, 2021 were analyzed. Selected clinical data of 37 389 subjects with 2 or more repeated ultrasound examinations, including 17 759 males, 19 630 females, aged (44.4±16.2) years, ranged from 22-103 years. 3 431 cases hepatic cyst were confirmed by repeated ultrasound examination, the data of the liver cyst formation after the same physical examination were the study group (n=3 431), and the data before cyst formation were the control group (n=3 431). The observation indicators included: (1) the epidemiological characteristics of liver cysts; (2) the age distribution of the incidence of liver cysts; (3) the gender distribution of the incidence of liver cysts; (4) the pathophysiological changes of liver cysts.Measurement data of normal distribution were expressed as mean±standard deviation (
±s). The measurement data of skewed distribution were expressed as M (Q1, Q3), using Wilcoxon signed rank sum test for comparing groups and chi-square test for comparing count data. The factors associated with hepatic cyst pathogenesis were summarized by multivariate Logistic regression.
ResultsThe overall incidence of hepatic cysts was 9.18%, 9.78% in males, 8.63% in females, and the incidence of males was greater than that of females. The incidence of males over 70 to 79 years old decreased slightly, and the incidence in males and females in the other age groups increased with age.Results of multivariate Logistic analysis showed age (OR=1.01, 95%CI: 1.01-1.02, P<0.01), waist circumference(OR=1.02, 95%CI: 1.01-1.02, P<0.01), systolic blood pressure (OR=1.00, 95%CI: 0.99-1.00, P=0.013), ALT (OR=0.99, 95%CI: 0.98-1.00, P<0.01), AST (OR=1.03, 95%CI: 1.02-1.04, P<0.01), triglyceride lipids (OR=0.90, 95%CI: 0.86-0.95, P<0.01), HDL(OR=0.71, 95%CI: 0.60-0.83, P<0.01), uric acid (OR=1.00, 95%CI: 1.00-1.00, P<0.01), creatinine (OR=0.99, 95%CI: 0.99-0.99, P<0.01) were the factors influencing the occurrence of liver cysts.
ConclusionsThe incidence of liver cysts increased linearly with age, and the incidence of males was greater than that of females. Age, waist circumference, systolic blood pressure, ALT, AST, triglycerides, HDL, uric acid, and creatinine may interact with the occurrence and development of liver cysts.
Key words:
Cysts; Pathologic processes; Physiological processes; Liver cyst; Onset characteristics; Correlative factor
Contributor Information
Gu Liguo
Department of Emergency, Liangxiang Hospital of Beijing Fangshan District, Beijing 102401, China
Zheng Yamin
Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Gao Xiang
Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Cai Jie
Department of Health Management, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Huang Yue
Department of Information Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Zhou Zhen
School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
±s)表示。偏态分布的计量资料以M(Q1，Q3)表示，组间比较采用Wilcoxon符号秩和检验；计数资料组间比较采用χ2检验。通过多因素Logistic回归分析总结肝囊肿致病的相关因素。
