To analyze the epidemiological characteristics of respiratory infectious disease pathogens during the spring of 2024 in Beijing, so as to provide reference basis for the diagnosis and treatment of respiratory infections in clinical practice as well as the prevention and control of epidemics.

Based on the Beijing respiratory pathogen monitoring system, samples of respiratory tract infection patients from 35 sentinel hospitals in 17 districts of Beijing and two children's hospitals in Beijing during period of the 17^th to 20^th weeks of 2024 were collected. The multiplexed real-time fluorescence polymerase chain reaction technology was used to detect 30 species/types of common respiratory pathogens. The corresponding epidemiological data were also collected.

During the period of 17^th to 20^th in the spring of 2024, 734 cases of respiratory infections were detected. The positive rates for respiratory viruses, Mycoplasma pneumoniae, and Chlamydia pneumoniae in the different age groups were 39.8% (33/83) in under 5 age group, 46.4% (77/166) in 5-17 age group, 26.5% (61/230) in 18-59 age group and 15.7% (40/255) in ≥60 age group. Rhinovirus ranked first in both the 18-59 and ≥60 age groups; M. pneumoniae was dominant in the under 5 and 5-17 age groups. The top 6 pathogen were Haemophilus influenzae, Streptococcus pneumoniae, rhinovirus, M. pneumoniae, Bordetella pertussis, parainfluenza virus, group A Streptococcus, and adenovirus and the positive rates were 30.16% (131/428), 12.15% (52/428), 11.68% (50/428), 11.68% (50/428), 6.78% (29/428), 5.14% (22/428), 5.14% (22/428) and 4.91% (21/428), respectively.

During the spring of 2024 in Beijing, the respiratory viruses were mainly rhinoviruses, parainfluenza viruses and adenoviruses. The bacterial and mycoplasma-like pathogen spectrum was dominated by H. influenzae, S. pneumoniae and M. pneumonia. Continuous strengthened surveillance of multiple respiratory pathogens would assist diagnosis, treatment, warning, and prediction of respiratory diseases.

Pathogen spectrum; Rhinovirus; Mycoplasma pneumoniae; Parainfluenza virus; Haemophilus influenzae; Streptococcus pneumoniae