Review
Recent advance in DTI-ALPS in evaluating cerebral glymphatic system and cerebral small vascular disease
Zhang Xue, Zhang Min, Yun Wenwei
Published 2024-08-15
Cite as Chin J Neuromed, 2024, 23(8): 854-858. DOI: 10.3760/cma.j.cn115354-20240717-00420
Abstract
Glymphatic system (GS), also known as glial-lymphatic system, plays a vital role in maintaining brain homeostasis. Previous research has established a link between cerebral small vessel disease (CSVD) and GS dysfunction. Diffusion tensor image analysis along the perivascular space (DTI-ALPS), an emerging non-invasive neuroimaging technique, has made significant strides in assessing GS function in central nervous system diseases. This review examines the DTI-ALPS principles, and relations of DTI-ALPS index with glymphatic circulation, various imaging markers of CSVD, and CSVD-related cognitive impairment, aiming to facilitate the early diagnosis, progression, and prognoses of CSVD.
Key words:
Glymphatic system; Diffusion tensor image analysis along the perivascular space; Cerebral small vessel disease; Neuroimaging biomarker; Cognitive impairment
Contributor Information
Zhang Xue
Department of Neurology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University (Changzhou Medical Center), Changzhou 213000, China
Zhang Min
Department of Neurology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University (Changzhou Medical Center), Changzhou 213000, China
Yun Wenwei
Department of Neurology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University (Changzhou Medical Center), Changzhou 213000, China
