中国前瞻性多中心出生队列（Prospective Omics Health Atlas birth cohort，POHA birth cohort）研究于2022年正式启动。本研究联合12个参与单位，旨在建设包含2万个自然妊娠家庭和辅助生殖家庭的高质量多维度队列，对亲代和子代进行长期随访，在重要的时间节点收集对应的生物标本。通过多组学检测和分析，开展母婴全生命周期的多组学大数据研究，以期寻找到母婴疾病新的生物标记物，为母体疾病和新生儿的健康相关的风险预测提供科学依据。
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深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
石家庄华大医学检验实验室有限公司，石家庄050000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
河北省母婴基因与健康产业技术研究院，石家庄 050000
石家庄华大医学检验实验室有限公司，石家庄050000
河北医科大学公共卫生学院，石家庄 050017
重庆医科大学附属妇女儿童医院、重庆市妇幼疾病预防控制与公共卫生研究中心，重庆401147
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
贵阳市妇幼保健院中心实验室，贵阳550000
贵阳市妇幼保健院孕产保健科，贵阳550000
济南市妇幼保健院产前诊断中心，济南 250001
济南市妇幼保健院产前诊断中心，济南 250001
大连妇幼保健院医务科，大连 116033
大连妇幼保健院医务科，大连 116033
内蒙古自治区妇幼保健院遗传科，呼和浩特010020
内蒙古自治区妇幼保健院产科，呼和浩特010020
上海市第一妇婴保健院胎儿医学科&产前诊断中心 201204
深圳华大基因股份有限公司，深圳518083
深圳华大基因股份有限公司，深圳518083
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
东莞市人民医院产科、东莞市妇产科重大疾病重点实验室，东莞 523058
郴州市第一人民医院产前诊断中心，郴州 423000
深圳市龙岗区妇幼保健院（汕头大学医学院龙岗妇幼临床学院）中心实验室，深圳 518100
深圳市龙岗区妇幼保健院（汕头大学医学院龙岗妇幼临床学院）中心实验室，深圳 518100
连云港妇幼保健院科教处生物资源库，连云港 222000
成都市妇女儿童中心医院产科，成都 611731
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
东莞市人民医院产科、东莞市妇产科重大疾病重点实验室，东莞 523058
成都市妇女儿童中心医院产前诊断科，成都 611731
连云港妇幼保健院中心实验室，连云港 222000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
重庆医科大学附属妇女儿童医院妇产科，重庆401147
东莞市人民医院产科、东莞市妇产科重大疾病重点实验室，东莞 523058
成都市妇女儿童中心医院产前诊断科，成都 611731
连云港妇幼保健院中心实验室，连云港 222000
深圳华大基因股份有限公司，深圳518083
河北省母婴基因与健康产业技术研究院，石家庄 050000
重庆医科大学附属妇女儿童医院妇产科，重庆401147
国家重点研发计划
（2022YFC2704700）
内蒙古自治区科技计划项目
（2021GG0130）
内蒙古自治区卫生健康委员会卫生科技计划项目
（202201138）
内蒙古自治区妇幼保健院院内科研项目
（2023FYYNB003）
所有作者声明无利益冲突
China prospective multicenter birth cohort (Prospective Omics Health Atlas birth cohort, POHA birth cohort) study was officially launched in 2022. This study, in collaboration with 12 participating units, aims to establish a high-quality, multidimensional cohort comprising 20 000 naturally conceived families and assisted reproductive families. The study involves long-term follow-up of parents and offspring, with corresponding biological samples collected at key time points. Through multi-omics testing and analysis, the study aims to conduct multi-omics big data research across the entire maternal and infant life cycle. The goal is to identify new biomarkers for maternal and infant diseases and provide scientific evidence for risk prediction related to maternal diseases and neonatal health.
Cohort studies; Birth cohort; Prospective study; Multi-center study; Multi-omics study
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Shijiazhuang BGI Medical Laboratory Co., Ltd., Shijiazhuang 050000, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Shijiazhuang BGI Medical Laboratory Co., Ltd., Shijiazhuang 050000, China
School of Public Health, Hebei Medical University, Shijiazhuang 050017, China
Chongqing Maternal and Child Disease Prevention and Control and Public Health Research Center, Chongqing Maternal and Child Health Hospital, Chongqing 401147, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Central Laboratory, Guiyang Maternal and Child Health Hospital, Guiyang 550000, China
Department of Maternal and Child Health, Guiyang Maternal and Child Health Hospital, Guiyang 550000, China
Prenatal Diagnosis Center, Jinan Maternal and Child Health Hospital, Jinan 250001, China
Prenatal Diagnosis Center, Jinan Maternal and Child Health Hospital, Jinan 250001, China
Medical Department, Dalian Maternal and Child Health Hospital, Dalian 116033, China
Medical Department, Dalian Maternal and Child Health Hospital, Dalian 116033, China
Department of Genetics, Inner Mongolia Maternal and Child Health Hospital, Hohhot 010020, China
Department of Obstetrics, Inner Mongolia Maternal and Child Health Hospital, Hohhot 010020, China
Department of Fetal Medicine &
Prenatal Diagnosis Center, Shanghai First Maternity and Infant Health Hospital, Shanghai 201204, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Department of Obstetrics, Dongguan People's Hospital
Dongguan Key Laboratory of Major Diseases in Obstetrics and Gynecology, Dongguan 523058, China
Prenatal Diagnosis Center, Chenzhou First People's Hospital, Chenzhou 423000, China
Central Laboratory, Shenzhen Longgang Maternal and Child Health Hospital (Longgang Maternal and Child Clinical College, Shantou University Medical College), Shenzhen 518100, China
Central Laboratory, Shenzhen Longgang Maternal and Child Health Hospital (Longgang Maternal and Child Clinical College, Shantou University Medical College), Shenzhen 518100, China
Biological Resource Bank of Science and Education Department, Lianyungang Maternal and Child Health Hospital, Lianyungang 222000, China
Department of Obstetrics, Chengdu Women's and Children's Central Hospital, Chengdu 611731, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Department of Obstetrics, Dongguan People's Hospital
Dongguan Key Laboratory of Major Diseases in Obstetrics and Gynecology, Dongguan 523058, China
Department of Prenatal Diagnosis, Chengdu Women's and Children's Central Hospital, Chengdu 611731, China
Central Laboratory, Lianyungang Maternal and Child Health Hospital, Lianyungang 222000, China
BGI Genomics Co., Ltd., Shenzhen 518083, China
Hebei Maternal and Child Genes and Health Industry Technology Research Institute, Shijiazhuang 050000, China
Department of Obstetrics and Gynecology, Chongqing Maternal and Child Health Hospital, Chongqing 401147, China
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