The process of lipid metabolism, from lipid uptake to oxidation, as well as the enzymes and transporters involved in lipid metabolism, and different lipids, all participate into the regulation of aging.On the contrary, aging and longevity signals regulate lipid metabolism.Lipid metabolism reprogramming is involved in the formation and maintenance of senescent cells, and lipid components are potential targets for identifying senescent cells.Intervention in lipid metabolism can serve as a potential strategy for senolytics and senmorphics.

Lipid metabolism; Aging; Cell senescence; Senotherapeutics