Systematic Reviews/Meta-analysis
Meta-analysis of the relationship between chronic non-occupational arsenic exposure and hypertension
Hu Huai, Lan Lan, Huang Hairu, Shen Binqing, Zhong Xiaoyan, Yang Qianlei, An Yan
Published 2024-08-20
Cite as Chin J Endemiol, 2024, 43(8): 670-677. DOI: 10.3760/cma.j.cn231583-20231218-00138
Abstract
ObjectiveTo systematically evaluate the correlation between chronic non-occupational arsenic exposure and hypertension.
MethodsA literature search was conducted through Web of Science, Pubmed, Embase, Cochrane Library, WanFang Data, China National Knowledge Infrastructure (CNKI), VIP Chinese Journal Service Platform (VIP) Database and China Biomedical Literature Database to comprehensively collect epidemiological literature related to chronic non-occupational arsenic exposure and hypertension published domestically and internationally for inclusion in the study, with a time limit from database establishment to January 1, 2023. Meta-analysis of dichotomous variables was conducted using Stata MP15 software, with odds ratio (OR) value [95%confidence interval(CI)] as the effect evaluation indicator. A random-effects model or a fixed-effects model was selected for comprehensive quantitative analysis according to the heterogeneity results; the sources of heterogeneity were identified through subgroup analysis; a funnel plot was used for qualitative analysis of publication bias and the results were further assessed by Egger test. Stata 15.0 software was then used to analyze the dose-response relationship between chronic non-occupational arsenic exposure and hypertension using restricted cubic spline function and generalized least squares estimation (GLST) method.
ResultsTwenty-nine articles (n = 127 258) were finally included, including 24 English articles and 5 Chinese articles. Through Meta-analysis, the combined OR value (95%CI) for hypertension was 1.07 (1.04 - 1.09), with a statistically significant difference (P < 0.05). The combined OR values (95%CI) for urinary arsenic, drinking water arsenic, and hair arsenic in subgroup analysis were 1.10 (1.04 - 1.17), 1.13 (1.07 - 1.20), and 2.55 (1.55 - 4.20), respectively. The combined OR values (95%CI) for cross-sectional studies, case-control studies and cohort studies were 1.11 (1.06 - 1.16), 1.13 (1.04 - 1.23) and 1.04 (1.00 - 1.07), respectively. For every unit (μg/L) increase in arsenic exposure in drinking water, the risk of hypertension increased by 0.13% [OR value (95%CI): 1.001 269 (1.000 104 - 1.002 434), P < 0.05].
ConclusionsThere is a correlation between chronic non-occupational arsenic exposure and adult hypertension, with urinary arsenic, drinking water arsenic and hair arsenic as possible exposure markers. There is a non-linear dose-response relationship between chronic non-occupational arsenic exposure and adult hypertension.
Key words:
Arsenic; Chronic non-occupational arsenic exposure; Hypertension; Meta-analysis
Contributor Information
Hu Huai
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
Lan Lan
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
Huang Hairu
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
Shen Binqing
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
Zhong Xiaoyan
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
Yang Qianlei
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
An Yan
School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215021, China
