Clinical Original Article
Association of systemic immunity-inflammation index with the risk of hyperuricemia: A cohort study
Xie Xiaoling, Miao Xinlei, Hu Manling, Liu Shuang, Song Ziping, Sun Yuting, Tang Guimin, Wang Qianqian, Leng Song
Published 2024-10-25
Cite as Chin J Endocrinol Metab, 2024, 40(10): 844-850. DOI: 10.3760/cma.j.cn311282-20240306-00086
Abstract
ObjectiveTo explore the correlation between systemic immunity-inflammation index(SII) and hyperuricemia(HUA).
MethodsParticipants who had at least 3 health checkups in the Health Management Center of the Second Affiliated Hospital of Dalian Medical University from January 2014 to December 2022 were selected to construct a dynamic cohort. The SII, reflecting the inflammatory state of the body, was constructed using neutrophil, platelet, and lymphocyte counts. A Cox proportional hazard regression model was used to explore the association between SII and HUA in the overall population and different subgroups of the population, and sensitivity analysis was performed twice.
ResultsA total of 20 022 subjects were included, and the mean follow-up time was 3.67 years. After adjusting for confounding factors, each unit increase in the natural logarithm of SII(lnSII) was associated with a 24% increased risk of hyperuricemia(HR=1.24, 95%CI 1.16-1.32, P<0.001). As a categorical variable, compared with the lowest quartile array(Q1), the risk of HUA in the total population increased by 12%(HR=1.12, 95%CI 1.03-1.21, P=0.006), 14%(HR=1.14, 95%CI 1.06-1.24, P=0.001), 27%(HR=1.27, 95%CI 1.17-1.37, P<0.001) in Q2, Q3 and Q4 groups within the general population, respectively. All subgroup analysis and sensitivity analysis showed that SII was positively correlated with HUA.
ConclusionsElevated levels of SII significantly increase the risk of HUA. Assessing the body′s inflammatory status using SII can aid in risk screening and preventive management for individuals at high risk of HUA.
Key words:
Systemic immunity-inflammation index; Hyperuricemia; Cohort study; Health examination
Contributor Information
Xie Xiaoling
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
Miao Xinlei
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
Hu Manling
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
Liu Shuang
School of Public Health, Dalian Medical University, Dalian 116000, China
Song Ziping
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
Sun Yuting
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
Tang Guimin
School of Public Health, Dalian Medical University, Dalian 116000, China
Wang Qianqian
School of Public Health, Dalian Medical University, Dalian 116000, China
Leng Song
Health Management Center of the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
