Relationship between nocturnal hypoglycemia and cognitive function in aged type 2 diabetic patients
Yuanyuan Chen, Hua Zhang, Gaozhong Huang
Published 2016-01-04
Cite as Chin J Gen Pract, 2016, 15(1): 43-46. DOI: 10.3760/cma.j.issn.1671-7368.2016.01.013
Abstract
Two hundred and eleven aged patients with type 2 diabetes were enrolled in the study. Blood glucose levels were monitored with continuing glucose monitoring system(CGMS) for 3 days and the cognitive function was evaluated with Mini-Mental State Examination(MMSE) scale. The correlation between hypoglycemia(or nocturnal hypoglycemia) and MMSE scores was evaluated. CGMS recorded hypoglycemia in 47% patients(100/211), 82% of whom(82/100) had nocturnal hypoglycemia. Patients with hypoglycemia had lower MMSE scores than those without hypoglycemia(25.1±5.1 vs. 26.8±3.0, P<0.05). Furthermore, the incidence of hypoglycemia(or nocturnal hypoglycemia) was higher in patients with MMSE≤24 than that in patients with MMSE>24(P<0.05). The median of hypoglycemia maximal time and nocturnal hypoglycemia maximal time were longer in patients with MMSE≤24 than those with MMSE>24(P<0.05). Stepwise regression analysis showed that the total time and maximal time of hypoglycemia(or nocturnal hypoglycemia), age, and education level were the main factors influencing MMSE scores in aged type 2 diabetic patients(all P<0.05).
Key words:
Diabetes mellitus, type 2, aged; Nocturnal hypoglycemia; Cognitive disorders; Retrospective study
Contributor Information
Yuanyuan Chen
Department of Geriatrics, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Hua Zhang
Gaozhong Huang
