Original Article
Clinical effect of different doses of fibrinolysin with statins on carotid atherosclerotic plaques
Xiaoling Guo, Lin Li, Yan Li, Weilai Li, Hui Sun, Yan Sun, Tianyi Wang
Published 2016-12-08
Cite as Chin Med, 2016, 11(12): 1781-1784. DOI: 10.3760/cma.j.issn.1673-4777.2016.12.010
Abstract
ObjectiveTo analyze the clinical effect of different doses of fibrinolysin with statins on carotid atherosclerotic plaques.
MethodsA total of 171 patients with carotid atherosclerotic plaques from January 2014 to January 2016 in No. 266 Hospital of Chinese People′s Liberation Army were randomly divided into control group(52 cases), fibrinolysin 100 U group(59 cases) and fibrinolysin 200 U group(60 cases). The control group was treated with aspirin enteric coated tablet 0.1 g/time, 1 time/d and atorvastatin calcium 20 mg/time, 1 time/d. The fibrinolysin 100 U group and fibrinolysin 200 U group were added fibrinolysin 100 U and 200 U respectively, with 1 time/d intravenous drop infusion for 10 d. At 6 months after treatment, clinical effective rate, the National Institute of Health stroke scale(NIHSS) score, carotid artery intima-media thickness and Crouse score were analyzed.
ResultsEffective rates in fibrinolysin 100 U group and fibrinolysin 200 U group were higher than that in control group[81.4%(48/59), 85.0%(51/60) vs 64.7%(33/51)], and the effective rate in fibrinolysin 200 U group was higher than that in fibrinolysin 100 U group, the differences were statistically significant(P<0.05). The NIHSS score and carotid artery intima-media thickness in fibrinolysin 200 U group were significantly lower than those in fibrinolysin 100 U group after treatment[(1.4±1.3) scores vs (2.3±1.4) scores, (2.2±1.0)mm vs (2.5±1.2)mm](P<0.05). The difference values of Crouse score before and after treatment in control group, fibrinolysin 100 U group and fibrinolysin 200 U group were 1.08, 0.97 and 1.42, respectively; there was statistically significant difference between fibrinolysin 100 U group and fibrinolysin 200 U group (P<0.05).
ConclusionThe efficacy data of fibrinolysin with statins in treating carotid atherosclerotic plaques is encouraging, the curative effect is associated with the dose of fibrinolysin.
Key words:
Carotid artery disease; Plaque, atherosclerotic; Cerebrovascular disorder; Fibrinolysin
Contributor Information
Xiaoling Guo
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Lin Li
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Yan Li
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Weilai Li
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Hui Sun
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Yan Sun
Department of Neurology, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
Tianyi Wang
Department of Orthopedics, No. 266 Hospital of Chinese People′s Liberation Army, Hebei Province, Chengde 067000, China
