To investigate the effect of patient-controlled intravenous analgesia(PCIA) with oxycodone and sulfentanyl on postoperative pain in patients after cesarean section.

Totally 110 primiparous women with term pregnancy who had cesarean section under subarachnoid anesthesia in Beijing YouAn Hospital, Capital Medical University from February to October 2016 were enrolled. The patients were randomly allocated to have PCIA with sulfentanyl(sulfentanyl group, 55 cases, sulfentanyl 150 μg+ 0.9% sodium chloride injection, 100 ml) and oxycodone(oxycodone group, 55 cases, oxycodone hydrochloride injection 50 mg+ 0.9% sodium chloride injection, 100 ml); PCIA was set as 2 ml/h continuous infusion and single additional dose of 0.5 ml with 15 min intervals. Visual Analogue Scale(VAS) was used to evaluate incision pain and uterine contraction pain 2, 4, 6, 8, 12, 24 h after operation. Satisfaction degree of postoperative analgesia was recorded. Adverse reactions were observed.

VAS scores of analgesia pain 8, 12, 24 h after operation in oxycodone group were significantly lower than those in sulfentanyl group[(3.0±1.3)scores vs (3.7±1.5)scores, (2.4±1.0)scores vs (3.2±1.5)scores, (1.4±1.1)scores vs (2.6±1.7)scores](P<0.05 or P<0.01). VAS scores of uterine contraction pain 2, 4, 6, 8, 24 h after operation in oxycodone group were significantly lower than those in sulfentanyl group[(2.2±0.6)scores vs (3.2±1.0)scores, (5.2±2.8)scores vs (6.8±1.7)scores, (5.2±1.6)scores vs (6.7±1.8)scores, (4.4±1.6)scores vs (5.6±2.1)scores, (1.6±1.5)scores vs (3.2±2.4)scores](P<0.05 or P<0.01). Satisfaction degree of postoperative analgesia in oxycodone group was significantly higher than that in sulfentanyl group(P<0.01 or P<0.05). Incidence of adverse reactions had no significant differences between groups(P>0.05).

Oxycodone has a better analgesia effect than sulfentanyl on patients after cesarean section.

Cesarean section; Patient-controlled intravenous analgesia; Oxycodone; Sulfentanyl