Objective To investigate the diagnostic difference between preoperative diagnostic curettage and postoperative pathological diagnosis in endometrial carcinoma,and provide guidance for the accuracy in preoperative diagnosis of endometrial carcinoma.Methods The data of 124 endometrial carcinoma patients were retrospectively analyzed,including clinical stage,pathological stage,pathological type,histologic grade,etc.Results In 124 endometrial carcinoma patients,102 cases of endometrial carcinoma were found by preoperative diagnostic curettage,the diagnostic accordance rate was 82.3％ (102/124),misdiagnosis was in 22 cases,the misdiagnosis rate was 17.7％(22/124).The total accordance rate of preoperative clinical stage and postoperative pathological stage was 81.4％ (83/102) in 102 patients who had the same preoperative and postoperative diagnosis,and the accordance rate of Ⅰ stage was 86.1％ (62/72),the accordance rate of Ⅱ stage was 72.0％(18/25),the accordance rate of Ⅲ stage was 3/5.The total accordance rate of preoperative diagnostic curettage histologic grade and postoperative pathological histologic grade was 65.7％(67/102),and the accordance rate of G1 grade was 55.6％ (25/45),the accordance rate of G2 grade was 69.2％ (27/39),the accordance rate of G3 grade was 15/18.Conclusions The pathological type,pathological stage and histologic grade of preoperative diagnostic curettage and postoperative pathological diagnosis in endometrial carcinoma are not always consistent.A variety of diagnostic methods should be considered together in order to reduce the diagnosis difference preoperative and postoperative,and improve the accordance rate of preoperative diagnosis.