Original Article
Clinical analysis of rightzopiclone on improvement of sleep disorders in patients with alzheimer's disease
Tan Liyang, Zhang Jun, Liu Min, Tang Wei
Published 2020-02-05
Cite as Chin J Postgrad Med, 2020, 43(2): 171-174. DOI: 10.3760/cma.j.issn.1673-4904.2020.02.017
Abstract
ObjectiveTo observe and analyze rightzopiclone on the improvement of sleep disorders in patients with Alzheimer disease.
MethodsEighty-four Alzheimer disease patients with sleep disorders admitted to the Department of Neurology of the Dalian University Affiliated Xinhua Hospital from August 2016 to August 2018 were selected and randomly divided into observation group and control group, with 42 patients in each group. The patients in the observation group were given rightzopiclone orally, while the patients in the control group were given alprazolam orally. The Pittsburgh Sleep Quality Index (PSQI) was applied to assess the sleep state of the two groups before and after the treatment.
ResultsThe total effective rates of sleep improvement in the observation group were 78.57% and 92.86% after 2 and 4 weeks of the treatment, which was significantly higher than that in the control group of 54.76% and 73.81% (P<0.05), and the PSQI assessment results were also significantly better than those in the control group (P<0.05).
ConclusionsRightzopiclone is helpful for the improvement of sleep state of Alzheimer disease patients with sleep disorders, and it has high clinical application value.
Key words:
Alzheimer disease; Sleep disorders; Rightzopiclone; Clinical improvement
Contributor Information
Tan Liyang
Department of Neurology, Dalian University Affiliated Xinhua Hospital, Dalian 116021, China
Zhang Jun
Liu Min
Tang Wei
