Xiaoting Wang, Zhangyong Xia, Chengju Huo, Ru Ban, Xin Zhao, Liuying Zhang, Guifeng Zhang, Li Li, Caisheng Lu, Bo Liu
Abstract
Atherosclerosis is a chronic systemic inflammatory disease caused by the interaction of environment and genetic factors. Epigenetic modification is a bridge between environmental factors and genetic factors. DNA methylation is an important regulatory mode of epigenetic modification, which can regulate gene expression at the pre-transcriptional level. Studies have shown that DNA methylation plays an important role in the occurrence and development process of atherosclerosis. Therefore, atherosclerosis-related DNA demethylation, especially carotid atherosclerosis-related DNA demethylation, can be achieved by natural or synthetic DNA demethylases, thereby achieving the purpose of preventing or treating atherosclerotic cerebrovascular disease. This article reviews DNA methylation and its relationship with atherosclerosis and DNA demethylation therapy.
Key words:
Atherosclerosis; DNA Methylation; Epigenesis, Genetic
Contributor Information
Xiaoting Wang
Graduate School of Taishan Medical University, Tai'an 271000, China
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Zhangyong Xia
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Chengju Huo
Department of Neurology, Liaocheng Third People's Hospital, Liaocheng 252000, China
Ru Ban
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Xin Zhao
Graduate School of Taishan Medical University, Tai'an 271000, China
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Liuying Zhang
Graduate School of Taishan Medical University, Tai'an 271000, China
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Guifeng Zhang
Graduate School of Taishan Medical University, Tai'an 271000, China
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Li Li
Graduate School of Taishan Medical University, Tai'an 271000, China
Department of Neurology, Liaocheng People's Hospital, the Research Center for Minimally Invasive Therapeutic Engineering of Cardiocerebrovascular Diseases of Shandong Province, Liaocheng 252000, China
Caisheng Lu
Dongchangfu District People's Hospital, Liaocheng 252002, China
Bo Liu
Dong'e County People's Hospital, Liaocheng 252201, China
