Original Article
Analysis of liver function and metabolism in patients with non-alcoholic fatty liver disease
Zhang Daiyi, Liu Dan, Xu Yan, Zhao Lingmei, Pu Jianhong
Published 2020-10-25
Cite as China Clin Pract Med, 2020, 11(5): 14-18. DOI: 10.3760/cma.j.cn115570-20200803.01105
Abstract
ObjectiveTo analyze the liver function and the metabolism in patients with non-alcoholic fatty liver disease(NAFLD).
MethodsA total of 11 041 medical examinees were selected by our hospital from January 2019 to December 2019.There were 6 935 males and 4 106 females, aged(49.9±12.9)years old, raging from 20 to 97 years old.Height, weight pressure, body mass index(BMI), fasting plasma glucose, glycosylated hemoglobin(HbA1c), triacylglycerol, total cholesterol, high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterin(LDL-C), alanine aminotransferase(ALT), aspartic acid amino transferase(AST)and serum uric acid were mesured.Abdominal ultrasound and cervical vascular ultrasound were performed.
ResultsNAFLD was diagnosed in 3 316 patients, including 2 697 males and 619 females.Compared the number of the infected males and females, the difference was statistically significant(P<0.01). The morbidity of males in different age compared with females, the difference was statistically significant(P<0.01). According to whether or not NAFLD, the patients were divided into NAFLD group and non-NAFLD group.Overweight or obesity, hypertension, diabetes, increased fasting plasma glucose, increased HbA1c, high ALT, high triacylglycerol, increased total cholesterol, increased LDL-C, decreased HDL-C, increased serum uric acid and the incidence of carotid plaque in NAFLD groupwere higher than non-NAFLD group, the difference was statistically significant(P<0.01). Multivariate analysis showed, the age, male, BMI, hypertension, diabetes, increased fasting plasma glucose, increased HbA1c, increased triacylglycerol, increased LDL-C, decreased HDL-C were closely related to the occurence of NAFLD.
ConclusionAge, male, overweight or obesity, hypertension, hyperglycemia, and hyperlipidemia are the main risk factors for fatty liver development, and also the risk factors for the development of cardiovascular and cerebrovascular diseases.Controlling fatty liver is positive significance for the prevention of cardiovascular and cerebrovascular diseases.
Key words:
Non-alcoholic fatty liver disease; Fat liver; Metabolic syndrome; Risk factors
Contributor Information
Zhang Daiyi
Department of Health Management Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Liu Dan
Department of Health Management Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Xu Yan
Department of Health Management Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Zhao Lingmei
Department of Health Management Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Pu Jianhong
Department of Health Management Center, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
