Original Article
The expression level and significance of thyroid function in gestational diabetes mellitus and hypertension disorders complicating pregnancy during different pregnancies
Che Lifan, Liu Yao, Zhang Ling, Fang Jun, Zhao Guangzong
Published 2021-02-25
Cite as China Clin Pract Med, 2021, 12(1): 8-11. DOI: 10.3760/cma.j.cn115570-20201222.02616
Abstract
ObjectiveTo investigate and analyze the expression level and significance of thyroid function indexes in gestational diabetes mellitus(GDM)and hypertension disorders complicating pregnancy(HDCP)in different pregnancy periods.
MethodsClinical data of 87 patients with GDM and 80 patients with HDCP admitted to the department of Obstetrics of Weifang Yidu Central Hospital from April 2017 to April 2020 were retrospectively analyzed.All patients were included in the GDM group and the HDCP group, with an age of(27.54±2.30)years old, ranging from 25 to 32 years old.In addition, 85 healthy pregnant women admitted at the same time were selected as the healthy group to compare the thyroid function indexes of GDM and HDCP patients at the first(≤13 weeks of gestation), the second(14 to 27 weeks of gestation), and the third(≥28 weeks of gestation).
ResultsThe thyroid stimulating hormone(TSH)level in the second trimester of the three groups was higher than that in the first trimester, and the TSH level in the third trimester was higher than that in the second trimester, with statistically significant differences(P<0.05). In the second and third trimester of pregnancy, the TSH value of HDCP group[(2.35±0.60)mIU/L and(2.37±1.09)mIU/L]was significantly higher than that of GDM group[(2.12±0.64)mIU/L]and(2.29±1.04)mIU/L]and healthy group[(1.96±0.51)mIU/L and(2.04±0.48)mIU/L], and the TSH value of GDM group was significantly higher than that of healthy group, and the differences were statistically significant(P<0.05). The level of free thyroxine(FT4)in the second trimester was lower than that in the first trimester, and the level of FT4 in the third trimester was lower than that in the second trimester, and the differences were statistically significant(P<0.05). FT4 value in GDM group[(7.15±1.62)pmol/L and(7.01±2.11)pmol/L]was significantly lower than that in HDCP group[(7.32±2.40)pmol/L and(7.16±2.15)pmol/L]and healthy group[(8.06±2.16)pmol/L and(7.79±2.47)pmol/L], FT4 value in HDCP group was significantly lower than that in healthy group, and the differences were statistically significant(P<0.05).
ConclusionThere are abnormal manifestations of thyroid function indexes in patients with GDM and HDCP, mainly with increased TSH and reduced FT4.With the increase in pregnancy, the level of TSH increases and the level of FT4 reduces more significantly.
Key words:
Thyroid function; Pregnancy period; Gestational diabetes mellitus; Hypertension disorders complicating pregnancy
Contributor Information
Che Lifan
Department of Obstetrics, Weifang Yidu Central Hospital, Weifang 262500, China
Liu Yao
Department of Gynecology, Weifang Yidu Central Hospital, Weifang 262500, China
Zhang Ling
Department of Obstetrics, Weifang Yidu Central Hospital, Weifang 262500, China
Fang Jun
Department of Orthopedics, Weifang Yidu Central Hospital, Weifang 262500, China
Zhao Guangzong
Department of Orthopedics, Weifang Yidu Central Hospital, Weifang 262500, China
