Quantitative computed tomography-derived abdominal visceral adipose tissue and cardiometabolic risk in a large-scale population
Dong Shengyong, Zha Xiaojuan, Ran Limei, Li Yongli, Chen Shuang, Gao Jianbo, Li Shaolin, Lu Yong, Zhang Yuqin, Ma Xiao, Li YueHua, Xiao Xigang, Gong Xiangyang, Yang Zehong, Chen Wei, Yang Yingying, Chen Bairu, Lyu Yingru, Wu Yan, Wu Jing, Zhao Kaiping, Fu Xiaoxia, Du Xia, Fu Haihong, Cheng Xiaoguang, Zeng Qiang
Abstract
ObjectiveTo investigate the relationship between abdominal visceral adipose tissue (VAT) and cardiometabolic risk (CMR) through quantitative computed tomography (QCT).
MethodsThe present study included 76226 participants. Abdominal fat areas were measured using the QCT Pro Model 4 system. Cardiometabolic indices were collected, including systolic and diastolic blood pressures, fasting plasma glucose, total cholesterol, triglyceride, and low-density and high-density lipoprotein cholesterols CMR score was the sum of abnormal blood pressure, fasting glucose, triglyceride, and high-density lipoprotein cholesterol. Restricted cubic spline and ordered logistic regression models were applied.
ResultsThe mean age was 50±13 years and the percentage of men was 58.8%. The level of VAT area was higher in men than in women (191.7±77.1 cm2 vs 116.4±56.2 cm2, P<0.0001 for all). After adjustment for age, the cardiometabolic indices except high-density lipoprotein cholesterol increased with increasing VAT area. When VAT area was 300 cm2, age-adjusted odds ratios and 95% confidence intervals of a CMR score ≥ 1 were 14.61 (13.31, 16.04) for men and 5.46 (4.06, 7.36) for women, and the age-adjusted probability of a CMR score ≥ 3 was 31.7% for men and 31.3% for women.
ConclusionsQCT-derived VAT is closely related to CMR. The findings suggest that measurement of visceral fat is recommended for the management of abdominal obesity in subjects who agree to undergo lung cancer screening via low-dose CT without additional radiation exposure.
Key words:
Abdominal fat; Visceral adipose tissue; Cardiometabolic risk; Quantitative computed tomography
Contributor Information
Dong Shengyong
Health Management Institute, the Second Medical Center &
National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Zha Xiaojuan
Department of Health Center, Yijishan hospital of Wannan medical college, Wuhu 241001, China
Ran Limei
Department of Health Center, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China
Li Yongli
Department of Health Management, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China
Chen Shuang
Department of Radiology, the Affiliated Huashan hospital of Fudan University, Shanghai 200040, China
Gao Jianbo
Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Li Shaolin
Department of Radiology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 519000, China
Lu Yong
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Zhang Yuqin
Department of Radiology, Ningbo Medical Center Li Huili Hospital, Ningbo 315040, China
Ma Xiao
China-Japan Friendship Hospital, Beijing 100029, China
Li YueHua
Shanghai Jiao Tong University Affiliated Ninth People's Hospital, Shanghai 200011, China
Xiao Xigang
Department of Radiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Gong Xiangyang
Department of Radiology, the People's Hospital of Zhejiang Province, Hangzhou 310014, China
Yang Zehong
Sun Yat-sen Memorial Hospital of the Sun Yat-sen University, Guangzhou 510235, China
Chen Wei
Department of Radiology, Southwest Hospital, Army Medical University, Chongqing 400038, China
Yang Yingying
Department of Health Center, Yijishan hospital of Wannan medical college, Wuhu 241001, China
Chen Bairu
Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China
Lyu Yingru
Department of Radiology, the Affiliated Huashan hospital of Fudan University, Shanghai 200040, China
Wu Yan
Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wu Jing
National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Zhao Kaiping
Department of Medical Record Management and Statistics, Beijing Jishuitan Hospital, Beijing 100035, China
Fu Xiaoxia
Editorial Office of the Chinese Health Management Journal, Beijing 100710, China
Du Xia
Department of Radiology, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China
Fu Haihong
Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China
Cheng Xiaoguang
Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China
Zeng Qiang
Health Management Institute, the Second Medical Center &
National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
