Original Article
Analysis of etiological composition and changing trend of chronic kidney disease
Wu Yu, Zhou Jingjing, Jiang Shimin, Zhang Zheng, Zhuo Li, Li Wenge
Published 2021-10-20
Cite as Chin J Health Manage, 2021, 15(5): 442-445. DOI: 10.3760/cma.j.cn115624-20210309-00115
Abstract
ObjectiveTo analyze the etiological composition and changing trends in chronic kidney disease.
MethodsCKD patients from our hospital were in cluded in the study from three separate periods, 173 patients from 1990-1991, 956 patients from 2009-2010, and 1440 patients from 2018-2019. The etiology of CKD in patients between the younger and middle-aged group and the elderly group were compared using the χ² test, and the Bonferroni method was used to correct the pairwise comparisons.
ResultsThe leading cause of CKD in 1990-1991, 2009-2010, and 2018-2019 was chronic glomerulonephritis (52%), chronic glomerulonephritis (35%), and diabetes (36%), respectively. The distribution of the etiologies was different signficantly among the three cohorts (χ²=74.375, P<0.001). Compared with 1990-1991, the percentage of CKD related to diabetes (χ²=14.847, P=0.001) and hypertension (χ²=12.279, P=0.002) significantly increased, while chronic glomerulonephritis showed a downward trend (χ²=19.976, P<0.001). Among the elderly CKD patients, the leading cause of CKD in the three cohorts was chronic glomerulonephritis (34%), diabetes (40%), and diabetes (43%), respectively. Conversely, diabetes and hypertension have become the predominant causes in 2009-2010 and 2018-2019. Although chronic glomerulonephritis remained the leading cause of CKD in the past 30 years, the percentage declined gradually among the younger and middle-aged patients with CKD. The percentage of CKD related to diabetes (χ²=31.345, P<0.001) and hypertension (χ²=15.485, P<0.001) significantly increased. In addition, in the 2018-2019 cohort, there were 494 patients with end-stage renal disease (ESRD), and the percentage of ESRD related to diabetes and hypertension were 48% and 37%, respectively.
ConclusionDiabetes and hypertension have become the predominant causes of CKD in Chinese elderly patients. Although chronic glomerulonephritis was the leading cause among the younger and middle-aged patients with CKD, the percentage declined gradually. Additionally, diabetes and hypertension were also the predominant causes of ESRD.
Key words:
Chronic kidney disease; Diabetes; Hypertension; Chronic glomerulonephritis; Elderly patients
Contributor Information
Wu Yu
Department of Nephrology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine Medical College Beijing 100029, China
Zhou Jingjing
Department of Nephrology, China-Japan Friendship Hospital, Capital Medical University Medical College, Beijing 100029, China
Jiang Shimin
Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China
Zhang Zheng
Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China
Zhuo Li
Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China
Li Wenge
Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China
